Defensins: defenders of human reproductive health

YJ Zhai, Y Feng, X Ma, F Ma - Human reproduction update, 2023 - academic.oup.com
BACKGROUND Reproductive tract infection is an important factor leading to male and
female infertility. Among female infertility factors, microbial and viral infections are the main …

Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?

LM de la Maza, TL Darville, S Pal - Expert review of vaccines, 2021 - Taylor & Francis
Introduction Chlamydia trachomatis is the most common sexually transmitted bacterial
pathogen in the world. Antibiotic treatment does not prevent against reinfection and a …

Immunopathogenesis of genital Chlamydia infection: insights from mouse models

J Dockterman, J Coers - Pathogens and Disease, 2021 - academic.oup.com
Chlamydiae are pathogenic intracellular bacteria that cause a wide variety of diseases
throughout the globe, affecting the eye, lung, coronary arteries and female genital tract …

The composition of the microbiota in the full-term fetal gut and amniotic fluid: a bovine cesarean section study

A Husso, L Lietaer, T Pessa-Morikawa… - Frontiers in …, 2021 - frontiersin.org
The development of a healthy intestinal immune system requires early microbial exposure.
However, it remains unclear whether microbial exposure already begins at the prenatal …

Outpatient sexually transmitted infection testing and treatment patterns in the United States: a real-world database study

R Lillis, L Kuritzky, Z Huynh, R Arcenas, A Hansra… - BMC Infectious …, 2023 - Springer
Background Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are the most
common notifiable sexually transmitted infections (STIs) in the United States. Because …

Drug delivery strategies for management of women's health issues in the upper genital tract

SK Patel, GR Valicherla, AC Micklo… - Advanced Drug Delivery …, 2021 - Elsevier
The female upper genital tract (UGT) hosts important reproductive organs including the
cervix, uterus, fallopian tubes, and ovaries. Several pathologies affect these organ systems …

Immunometabolic Analysis of Mobiluncus mulieris and Eggerthella sp. Reveals Novel Insights Into Their Pathogenic Contributions to the Hallmarks of Bacterial …

R McKenzie, JD Maarsingh, P Łaniewski… - Frontiers in cellular …, 2021 - frontiersin.org
The cervicovaginal microbiome plays an important role in protecting women from dysbiosis
and infection caused by pathogenic microorganisms. In healthy reproductive-age women …

Microenvironment of the lower reproductive tract: focus on the cervical mucus plug

S Ruiz-Durán, CM Tenorio… - Seminars in …, 2024 - thieme-connect.com
The female lower reproductive tract microbiota is a complex ecosystem comprising various
microorganisms that play a pivotal role in maintaining women's reproductive well-being …

The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction

SC Walsh, JR Reitano, MS Dickinson, M Kutsch… - Cell host & …, 2022 - cell.com
Chlamydia trachomatis is the leading cause of sexually transmitted bacterial infections and a
major threat to women's reproductive health in particular. This obligate intracellular …

Induction of Protection in Mice against a Chlamydia muridarum Respiratory Challenge by a Vaccine Formulated with the Major Outer Membrane Protein in …

DF Tifrea, W He, S Pal, AC Evans, SF Gilmore… - Vaccines, 2021 - mdpi.com
Chlamydia trachomatis is a sexually transmitted bacterium that infects over 130 million
individuals worldwide annually. To implement a vaccine, we developed a cell-free co …