Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

The cellular senescence definition comes to the fact of cells irreversible proliferation
disability. Besides the cell cycle arrest, senescent cells go through some morphological …

Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated
tumor suppressor genes in human cancers, especially in glioma, and recent findings …

Abstract Purpose: Pancreatic neuroendocrine tumors (PanNET) are a heterogeneous group
of neoplasms with increasing incidence and unpredictable behavior. Whole-exome …

Simple Summary Cells undergoing malignant transformation must circumvent replicative
senescence and eventual cell death associated with progressive telomere shortening that …

An increasing number of epilepsies are being attributed to variants in genes with epigenetic
functions. The products of these genes include factors that regulate the structure and …

Nucleosomes wrap DNA and impede access for the machinery of transcription. The core
histones that constitute nucleosomes are subject to a diversity of posttranslational …

Deposition of replication-independent histone variant H3. 3 into chromatin is essential for
many biological processes, including development and reproduction. Unlike replication …

Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …