Fibroblast-like synoviocytes or synovial fibroblasts (FLS) are important cellular components
of the inner layer of the joint capsule, referred to as the synovial membrane. They can be …

Alopecia areata is an autoimmune hair loss disease that is non-scarring and is
characterized by chronic inflammation at the hair follicle level. Clinically, patients' …

Background Vascular activation is characterized by increased proinflammatory, pro
thrombotic, and proadhesive signaling. Several chronic and acute conditions, including Bcr …

Alkali burn-induced corneal inflammation and subsequent corneal neovascularization
(CNV) are major causes of corneal opacity and vision loss. M1 macrophages play a central …

The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …

Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine
storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been …

Spondyloarthritis (SpA) is a family of chronic inflammatory diseases, being the most
prevalent ankylosing spondylitis (AS) and psoriatic arthritis (PsA). These diseases share …

Atopic dermatitis (AD) is a common inflammatory skin disease caused by an immune
disorder. Mast cells are known to be activated and granulated to maintain an allergic …

ABSTRACT Introduction The Janus kinase family includes four members–JAK1, JAK2,
JAK3, TYK2-that are selectively associated with type I and II cytokine receptors. Jak …

SAPHO syndrome is an autoinflammatory disease with a variety of clinical manifestations,
which may be accompanied by other systemic inflammatory diseases in addition to the …