Aging is a major risk factor of high incidence and increased mortality of acute respiratory
distress syndrome (ARDS). Here, we demonstrated that persistent lung injury and high …

The deaminase ADAR1 edits adenosines in nuclear transcripts of nervous tissue and is
required in the fetal liver of the developing mouse embryo. Here we show by inducible gene …

Background—The blood–brain barrier (BBB) formed by brain endothelial cells
interconnected by tight junctions is essential for the homeostasis of the central nervous …

• Introduction• The proof‐of‐concept in vivo: the cell, the read‐out and the animal model‐The
CEPC: Still a putative cell‐Do CEPCs play an essential role in vascular (patho) physiology …

The vasculature plays an indispensible role in organ development and maintenance of
tissue homeostasis, such that disturbances to it impact greatly on developmental and …

Despite available therapies, myocardial infarction (MI) remains a leading cause of death
worldwide. Better understanding of the molecular and cellular mechanisms that regulate …

Over the past few decades, biologists have identified key molecular signatures associated
with a wide range of human cancers. Recently, animal models have been particularly useful …

Accumulating evidence indicates the impact of endothelial progenitor cells (EPCs) in
vascular repair. In patients, the number of EPCs is negatively correlated with the severity of …

Cancer stem cells (CSC) are predicted to be critical drivers of tumor progression due to their
self-renewal capacity and limitless proliferative potential. An emerging area of research …

FDA approval of several inhibitors of the VEGF pathway has enabled significant advances in
the therapy of cancer and neovascular age-related macular degeneration. However, similar …