The anatomy and physiology of the microcirculation in human skin are complex. Normal
cutaneous microcirculation is organized in two parallel plexuses with capillary loops …

Glucose toxicity is a well-established entity that has been shown in animal models of
diabetes to contribute to development of insulin resistance and impaired insulin secretion. In …

To assess the extent to which the progression of diabetic retinopathy can be arrested by
improved glycemic control, 35 normal dogs were randomly divided into a nondiabetic and …

OBJECTIVE To compare the incidence of severe hypoglycemia in patients crossed over
from multiple daily injections (MDIs) of insulin to continuous subcutaneous insulin infusion …

To identify events and mechanisms that might contribute to the poor reversibility of diabetic
complications, we examined whether diabetes or high glucose induces changes in gene …

Diabetes mellitus is a chronic disease characterized by hyperglycemia and by complications
that include microvascular disease of the eye and kidney and a variety of clinical …

Diabetes microangiopathy, a hallmark complication of diabetes, is characterised by
structural and functional abnormalities within the intricate network of microvessels beyond …

Diabetic foot disease and ulceration is a major complication that may lead to the amputation
of the lower limbs. Microangiopathy may play a significant role in the pathogenesis of tissue …

The major toll of diabetes mellitus, in terms of morbidity, mortality, and economic burden, is
the consequence of the devastating chronic complications of the disease. The most …

Multiple factors, including altered levels of vasoactive substances, altered vasomotor
responsiveness, chronic plasma volume expansion, and tissue hypoxia, contribute to a state …