The multifaceted role of HSF1 in pathophysiology: Focus on its interplay with TG2
L Occhigrossi, M D'Eletto, N Barlev… - International Journal of …, 2021 - mdpi.com
The cellular environment needs to be strongly regulated and the maintenance of protein
homeostasis is crucial for cell function and survival. HSF1 is the main regulator of the heat …
homeostasis is crucial for cell function and survival. HSF1 is the main regulator of the heat …
Recruitment of cellular prion protein to mitochondrial raft-like microdomains contributes to apoptosis execution
V Mattei, P Matarrese, T Garofalo, A Tinari… - Molecular biology of …, 2011 - Am Soc Cell Biol
We examined the possibility that cellular prion protein (PrPC) plays a role in the receptor-
mediated apoptotic pathway. We first found that CD95/Fas triggering induced a redistribution …
mediated apoptotic pathway. We first found that CD95/Fas triggering induced a redistribution …
Phosphorylation of transglutaminase 2 by PKA at Ser216 creates 14-3-3 binding sites
S Mishra, LJ Murphy - Biochemical and biophysical research …, 2006 - Elsevier
Transglutaminase 2 (TG2) is a multifunctional ubiquitous enzyme which is present in various
cellular compartments and is subject to phosphorylation by PKA. To better understand the …
cellular compartments and is subject to phosphorylation by PKA. To better understand the …
Phosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTEN
Y Wang, SR Ande, S Mishra - BMC cancer, 2012 - Springer
Abstract Background Transglutaminase 2 (TG2) and its phosphorylation have been
consistently found to be upregulated in a number of cancer cell types. At the molecular level …
consistently found to be upregulated in a number of cancer cell types. At the molecular level …
[PDF][PDF] Tissue transglutaminase (TG2) and mitochondrial function and dysfunction
TS Lai, CJ Lin, YT Wu, CJ Wu - Front. Biosci, 2017 - article.imrpress.com
Introduction 3. TG2: a multifunctional enzyme. 3.1. Transamidation Reaction (TGase
function) 3.1. 1. Inter-or intra-molecular crosslinking 3.1. 2. Aminylation 3.1. 3. Deamidation …
function) 3.1. 1. Inter-or intra-molecular crosslinking 3.1. 2. Aminylation 3.1. 3. Deamidation …
Caspase cleavage of HER-2 releases a Bad-like cell death effector
AM Strohecker, F Yehiely, F Chen, VL Cryns - Journal of Biological …, 2008 - ASBMB
Human epidermal growth factor receptor-2 (HER-2/ErbB2/neu), a receptor tyrosine kinase
that is amplified/overexpressed in poor prognosis breast carcinomas, confers resistance to …
that is amplified/overexpressed in poor prognosis breast carcinomas, confers resistance to …
Biological Implications and Functional Significance of Transglutaminase Type 2 in Nervous System Tumors
M Buccarelli, G Castellani, V Fiorentino, C Pizzimenti… - Cells, 2024 - mdpi.com
Transglutaminase type 2 (TG2) is the most ubiquitously expressed member of the
transglutaminase family. TG2 catalyzes the transamidation reaction leading to several …
transglutaminase family. TG2 catalyzes the transamidation reaction leading to several …
Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson's disease
R Verhaar, B Drukarch, JGJM Bol… - Neurobiology of …, 2012 - Elsevier
Parkinson's disease (PD) is characterized by accumulation of α-synuclein aggregates and
degeneration of melanized, catecholaminergic neurons. The tissue transglutaminase (tTG) …
degeneration of melanized, catecholaminergic neurons. The tissue transglutaminase (tTG) …
Changing faces, unmasking the beta-cell: post-translational modification of antigens in type 1 diabetes
M van Lummel, A Zaldumbide… - Current Opinion in …, 2013 - journals.lww.com
PTMs of beta-cell autoantigens provide a novel hypothesis to understand how autoreactive
T-cells can escape immune tolerance and cause destruction of beta-cells ('beta-cell …
T-cells can escape immune tolerance and cause destruction of beta-cells ('beta-cell …
Tgm2 alleviates LPS-induced apoptosis by inhibiting JNK/BCL-2 signaling pathway through interacting with Aga in macrophages
S Zhang, B Fu, Y Xiong, Q Zhao, S Xu, X Lin… - International …, 2021 - Elsevier
Sepsis is an unusual systemic infection caused by bacteria, which is a life-threatening organ
dysfunction. The innate immune system plays an important role in this process; however, the …
dysfunction. The innate immune system plays an important role in this process; however, the …