В нормальной ткани клеточный гомеостаз в значительной степени обусловлен двумя
катаболическими путями: апоптозом и аутофагией. Апоптоз, или запрограммированная …

Tissue transglutaminase (TGC or TG2) functions as transglutaminase (cross‐linking),
deamidase, kinase, and disulfide isomerase and its activities are implicated in the …

Transamidations are calcium‐dependent reactions catalyzed by transglutaminase enzymes.
Tissue transglutaminase (TG2 or TGC) is a multifunctional protein with a controversial role in …

Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with complex
carcinogenesis. Although there has been significant progress in the treatment of HCC over …

Pro‐and anti‐apoptotic members of the Bcl‐2 family are fundamental in the control of
apoptosis. Among them, Bax plays a key role in apoptosis induction by mediating the …

Abstract Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the
crosslinking between Gln and Lys residues and involved in various pathophysiological …

One of the unique characteristics of the transglutaminase (TG) family enzymes is multiple
distribution of the members. It is known that TGs exist in the cytosol, plasma membrane …

Transglutaminases are Ca2+‐dependent enzymes that post‐translationally modify proteins
by crosslinking or polyamination at specific polypeptide‐bound glutamine residues …

Intraneuronal depositions of α‐synuclein have been implicated in the pathogenesis of
Parkinsons′ s disease (PD). Previous reports have identified the crosslinking between α …