Pathophysiology of Migraine : CONTINUUM: Lifelong Learning in Neurology Account Register
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Migraine is a highly prevalent, disabling and complex episodic brain disorder whose
pathogenesis is poorly understood, due in part to the lack of valid animal models. Here we …

Migraine attacks can involve changes of appetite: while fasting or skipping meals are often
reported triggers in susceptible individuals, hunger or food craving are reported in the …

Objective.—This study tests the hypothesis that injury to the somatosensory cortex is
associated with periorbital allodynia and increases in nociceptive neuropeptides in the …

Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator
implicated in the pathophysiology of migraine. It binds to the extracellular domains of …

Pain is a clinical syndrome arising from a variety of etiologies in a heterogeneous
population, which makes successfully treating the individual patient difficult. Organizations …

Enhanced sensitivity to light (photophobia) and patterns is common in migraine and can be
regarded as visual allodynia. We aimed to develop and validate a questionnaire to easily …

The neuropeptide calcitonin gene-related peptide (CGRP) plays a critical role in the
pathophysiology of migraine. We have focused on the role of CGRP in photophobia, which …

Migraine is a complex neurological disorder with a significant impact on patients and
society. Clinical and preclinical studies have established the neuropeptide calcitonin gene …

Cortical spreading depolarisation (CSD), the neural mechanism underlying migraine aura,
may cause headache by sensitising the trigeminal system. Photophobia, the most …