Background Calcitonin gene-related peptide is recognized as a key player in migraine, yet
the mechanisms and sites of calcitonin gene-related peptide action remain unknown. The …

Migraine is a highly disabling neurological pain disorder in which management is frequently
problematic. Most abortive and preventative treatments employed are classically non …

Controversy exists as to when conscious pain perception in the fetus may begin. According
to the hypothesis of cortical necessity, thalamocortical connections, which do not form until …

2012-08-01 Assigned to ALDERBIO HOLDINGS LLC reassignment ALDERBIO HOLDINGS
LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …

In recent years bench-based studies have greatly enhanced our understanding of headache
pathophysiology, while facilitating the development of new headache medicines. At present …

The neuropeptide calcitonin gene-related peptide (CGRP) is a major player in migraine
pathophysiology. Previous preclinical studies demonstrated that intracerebroventricular …

Background: Migraine is a common disabling neurological disorder where attacks have
been recognized to consist of more than headache. The premonitory, headache, and …

Introduction: Migraine is one of the most common neurological disorders. Nowadays, the 5-
HT1B/1D receptor agonists, namely triptans, are considered as the standard of care for …

Calcitonin gene-related peptide (CGRP) is considered a major player in migraine
pathophysiology. However, the location and mechanisms of CGRP actions in migraine are …

Objective To evaluate whether intraganglionic calcitonin gene-related peptide induced
differential migraine-like responses in male and female rats. Methods Calcitonin gene …