[HTML][HTML] How many kinases are druggable? A review of our current understanding
There are over 500 human kinases ranging from very well-studied to almost completely
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …
[HTML][HTML] JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
A Sarapultsev, E Gusev, M Komelkova, I Utepova… - Molecular …, 2023 - Springer
The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …
as a cornerstone in cellular signaling, regulating physiological and pathological processes …
[HTML][HTML] Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
J Pous, B Baginski, P Martin-Malpartida… - Nature …, 2023 - nature.com
Many functional aspects of the protein kinase p38α have been illustrated by more than three
hundred structures determined in the presence of reducing agents. These structures …
hundred structures determined in the presence of reducing agents. These structures …
Dynamic applicability domain (dAD): compound–target binding affinity estimates with local conformal prediction
Motivation Increasing efforts are being made in the field of machine learning to advance the
learning of robust and accurate models from experimentally measured data and enable …
learning of robust and accurate models from experimentally measured data and enable …
JAK inhibitors and black box warnings: what is the future for JAK inhibitors?
ABSTRACT Introduction Janus kinase inhibitors (JAKi) have dramatically improved the
treatment of various autoimmune and myeloproliferative disorders. Recently, concern has …
treatment of various autoimmune and myeloproliferative disorders. Recently, concern has …
[HTML][HTML] Navigating the Immune Maze: Pioneering Strategies for Unshackling Cancer Immunotherapy Resistance
Simple Summary Cancer treatments have made remarkable advances with the introduction
of immunotherapy, which recruits the body's immune system to fight cancer. Despite these …
of immunotherapy, which recruits the body's immune system to fight cancer. Despite these …
The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells
J Kumagai, M Kiuchi, K Kokubo… - Proceedings of the …, 2023 - National Acad Sciences
Uncontrolled type 2 immunity by type 2 helper T (Th2) cells causes intractable allergic
diseases; however, whether the interaction of CD4+ T cells shapes the pathophysiology of …
diseases; however, whether the interaction of CD4+ T cells shapes the pathophysiology of …
[HTML][HTML] Small-molecule agents for cancer immunotherapy
F Wang, K Fu, Y Wang, C Pan, X Wang, Z Liu… - … Pharmaceutica Sinica B, 2023 - Elsevier
Cancer immunotherapy, exemplified by the remarkable clinical benefits of the immune
checkpoint blockade and chimeric antigen receptor T-cell therapy, is revolutionizing cancer …
checkpoint blockade and chimeric antigen receptor T-cell therapy, is revolutionizing cancer …
Kinase inhibitors: 20 years of success and many new challenges and recent trends in their patents
MAM Aboul-Soud, YA Al-Sheikh… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Protein kinases (PKs) play key roles in cellular signaling and
regulation cascades and therefore are listed among the most investigated enzymes with the …
regulation cascades and therefore are listed among the most investigated enzymes with the …
Integrating the analysis of human biopsies using post‐translational modifications proteomics
S Bhardwaj, M Bulluss, A D'Aubeterre… - Protein …, 2024 - Wiley Online Library
Proteome diversities and their biological functions are significantly amplified by post‐
translational modifications (PTMs) of proteins. Shotgun proteomics, which does not typically …
translational modifications (PTMs) of proteins. Shotgun proteomics, which does not typically …