There are over 500 human kinases ranging from very well-studied to almost completely
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …

The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …

Many functional aspects of the protein kinase p38α have been illustrated by more than three
hundred structures determined in the presence of reducing agents. These structures …

Motivation Increasing efforts are being made in the field of machine learning to advance the
learning of robust and accurate models from experimentally measured data and enable …

ABSTRACT Introduction Janus kinase inhibitors (JAKi) have dramatically improved the
treatment of various autoimmune and myeloproliferative disorders. Recently, concern has …

Simple Summary Cancer treatments have made remarkable advances with the introduction
of immunotherapy, which recruits the body's immune system to fight cancer. Despite these …

Uncontrolled type 2 immunity by type 2 helper T (Th2) cells causes intractable allergic
diseases; however, whether the interaction of CD4+ T cells shapes the pathophysiology of …

Cancer immunotherapy, exemplified by the remarkable clinical benefits of the immune
checkpoint blockade and chimeric antigen receptor T-cell therapy, is revolutionizing cancer …

ABSTRACT Introduction Protein kinases (PKs) play key roles in cellular signaling and
regulation cascades and therefore are listed among the most investigated enzymes with the …

Proteome diversities and their biological functions are significantly amplified by post‐
translational modifications (PTMs) of proteins. Shotgun proteomics, which does not typically …