Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis
(OA), a prevalent progressive degenerative joint disease that causes debilitating pain …

Sensation of mechanical stimuli by chondrocytes is critical to cartilage homeostasis and
osteoarthritis development. The earliest responses in chondrocyte mechanotransduction …

Osteoarthritis (OA) is a degenerative disease that is difficult to cure owing to its complicated
pathogenesis. Exercise therapy has been endorsed as a primary treatment option. However …

Purpose The stiffness of the pericellular matrix (PCM) decreases in the most common
degenerative joint disease, osteoarthritis (OA). This study was undertaken to explore the …

Osteoarthritis (OA) is a currently incurable, chronic, progressive, and debilitating
musculoskeletal (MSK) condition. One of its hallmark symptoms is chronic nociceptive and …

Articular cartilage and their chondrocytes are physiologically submitted to diverse types of
mechanical cues. Chondrocytes produce and maintain the cartilage by sensing and …

Spaceflight and simulated spaceflight microgravity induced osteoarthritic-like alterations at
the transcriptomic and proteomic levels in the articular and meniscal cartilages of rodents …

The unique structure and composition of articular cartilage is critical for its physiological
function. However, this architecture may get disrupted by degeneration or trauma. Due to the …

Mechanical stimuli regulate the chondrogenic differentiation of mesenchymal stem cells and
the homeostasis of chondrocytes, thus affecting implant success in cartilage tissue …

Osteoarthritis (OA) is the most common degenerative joint disease causing pain and
functional limitations. Physical activity as a clinically relevant, effective intervention alleviates …