TGF‐β superfamily co‐receptors in cancer

JB Pawlak, GC Blobe - Developmental Dynamics, 2022 - Wiley Online Library
Transforming growth factor‐β (TGF‐β) superfamily signaling via their cognate receptors is
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …

Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling

KY Lee, PW Shueng, CM Chou, BX Lin, MH Lin… - Cancer …, 2020 - Wiley Online Library
Lung cancer is the most commonly diagnosed cancer worldwide, and metastasis in lung
cancer is the leading cause of cancer‐related deaths. Thus, understanding the mechanism …

[HTML][HTML] CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma

XT Mo, THY Leung, HWM Tang, MKY Siu… - British Journal of …, 2020 - nature.com
Background CD109 was involved in the tumorigenesis and progression of various cancers
via TGF-β1 signalling and STAT3 activation. As CD109 is strongly expressed in cervical …

The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review

HM Al‐kuraishy, TJ Al‐Maiahy, AI Al‐Gareeb… - Cancer …, 2024 - Wiley Online Library
Background Endometrial adenocarcinoma (EAC) is a malignant tumor of the endometrium.
EAC is the most common female malignancy following the menopause period. About 40% of …

[HTML][HTML] Upregulation of CD109 promotes the epithelial-to-mesenchymal transition and stemness properties of lung adenocarcinomas via activation of the hippo-YAP …

KY Lee, TC Kuo, CM Chou, WJ Hsu, WC Lee, JZ Dai… - Cells, 2020 - mdpi.com
Metastasis is the leading cause of death in lung adenocarcinomas. Identifying potential
prognostic biomarkers and exploiting regulatory mechanisms could improve the diagnosis …

Gallbladder squamous cell carcinoma: an analysis of 1084 cases from the National Cancer Database

RI Ayabe, MM Wach, SM Ruff, LP Diggs… - Journal of surgical …, 2020 - Wiley Online Library
Abstract Background/Objectives Gallbladder squamous cell carcinoma (SCC) is an
uncommon malignancy whose rarity has made it particularly challenging to study. We …

[HTML][HTML] CD109 is a critical determinant of EGFR expression and signaling, and tumorigenicity in squamous cell carcinoma cells

S Zhou, A Hassan, T Kungyal, S Tabariès, JLRG Luna… - Cancers, 2022 - mdpi.com
Simple Summary Squamous cell carcinoma is a type of cancer resulting from cancer of the
squamous cells that line some organs of the body such as the skin, lungs, and vulva. It is …

Mechanical force-activated CD109 on periodontal ligament stem cells governs osteogenesis and osteoclast to promote alveolar bone remodeling

Y Li, Y Li, C Liu, X Yu, Z Gan, L Xiang… - Stem Cells …, 2024 - academic.oup.com
Mechanical force-mediated bone remodeling is crucial for various physiological and
pathological processes involving multiple factors, including stem cells and the immune …

Long-read RNA sequencing of Pacific abalone Haliotis discus hannai reveals innate immune system responses to environmental stress

Y Sun, X Zhang, Y Wang, Z Zhang - Fish & Shellfish Immunology, 2022 - Elsevier
Haliotis discus hannai is a commercially important mollusk species, and the abalone
aquaculture sector has been jeopardized by deteriorating environmental circumstances …

CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells

Y Hatsuzawa, K Yamaguchi, T Takanashi, I Sato… - Pancreatology, 2020 - Elsevier
Background Accumulating evidence indicates that CD109, a glycosylphosphatidylinositol-
anchored glycoprotein, is highly expressed in human epithelial carcinomas of multiple …