Computational models can be applied to optimize treatment schedules and model treatment
responses in cancer therapy. In this Review, we provide an overview of such computational …

Simple Summary Lactic acidosis is a prominent feature of the tumour microenvironment and
a key player in cancer metabolism. This review is aimed at combining the mechanisms …

Cells are the basic units of all living matter which harness the flow of energy to drive the
processes of life. While the biochemical networks involved in energy transduction are well …

Aberrant metabolism has been identified as a main driver of cancer. Profiling of metabolism-
related pathways in cancer furthers the understanding of tumor plasticity and identification of …

This review focuses on the evolving understanding that we have of tumor cell metabolism,
particularly glycolytic and oxidative metabolism, and traces back its evolution through time …

Cancer cells show several metabolic phenotypes depending on the cancer types and the
microenvironments in tumor tissues. The glycolytic phenotype is one of the hallmarks of …

Background Pancreatic cancer is a fatal tumor, which is one of the most common malignant
tumors at present. Patients with pancreatic cancer also respond poorly to chemotherapy or …

We describe a strategy for the development of a rational approach of neoplastic disease
therapy based on the demonstration that scale-free networks are susceptible to specific …

Targeting cancer cell metabolism has been an attractive approach for cancer treatment.
However, the role of metabolic alternation in cancer is still unknown whether it functions as a …

Oxygenation of tumors and the effect of hypoxia on cancer cell metabolism is a widely
studied subject. Hypoxia‐inducible factor (HIF), the main actor in the cell response to …