Mechanisms of action of currently used antiseizure drugs
GJ Sills, MA Rogawski - Neuropharmacology, 2020 - Elsevier
Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …
have disease-modifying properties. In the more than 160 years that orally administered …
Challenges of neuropathic pain: focus on diabetic neuropathy
DC Rosenberger, V Blechschmidt… - Journal of Neural …, 2020 - Springer
Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …
Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain
K Wang, S Wang, Y Chen, D Wu, X Hu, Y Lu, L Wang… - Cell research, 2021 - nature.com
Peripheral nerve injury could lead to chronic neuropathic pain. Understanding
transcriptional changes induced by nerve injury could provide fundamental insights into the …
transcriptional changes induced by nerve injury could provide fundamental insights into the …
Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale
The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …
calcium channels. Initially licensed for pain and seizures, they have become widely …
Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1
Astrocytes control excitatory synaptogenesis by secreting thrombospondins (TSPs), which
function via their neuronal receptor, the calcium channel subunit α2δ-1. α2δ-1 is a drug …
function via their neuronal receptor, the calcium channel subunit α2δ-1. α2δ-1 is a drug …
Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states
RA Dampney, LC Michelini, DP Li… - American Journal of …, 2018 - journals.physiology.org
The hypothalamic paraventricular nucleus (PVN) is a unique and important brain region
involved in the control of cardiovascular, neuroendocrine, and other physiological functions …
involved in the control of cardiovascular, neuroendocrine, and other physiological functions …
Tiam1 coordinates synaptic structural and functional plasticity underpinning the pathophysiology of neuropathic pain
Neuropathic pain is a common, debilitating chronic pain condition caused by damage or a
disease affecting the somatosensory nervous system. Understanding the pathophysiological …
disease affecting the somatosensory nervous system. Understanding the pathophysiological …
Genetic associations between voltage-gated calcium channels and psychiatric disorders
Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
TIAM1-mediated synaptic plasticity underlies comorbid depression–like and ketamine antidepressant–like actions in chronic pain
Q Ru, Y Lu, AB Saifullah, FA Blanco… - The Journal of …, 2022 - Am Soc Clin Investig
Chronic pain often leads to depression, increasing patient suffering and worsening
prognosis. While hyperactivity of the anterior cingulate cortex (ACC) appears to be critically …
prognosis. While hyperactivity of the anterior cingulate cortex (ACC) appears to be critically …
Epigenetic mechanisms of neural plasticity in chronic neuropathic pain
Neuropathic pain is a challenging clinical problem and remains difficult to treat. Altered gene
expression in peripheral sensory nerves and neurons due to nerve injury is well …
expression in peripheral sensory nerves and neurons due to nerve injury is well …