Protein kinases play vital roles in controlling cell behavior, and an array of kinase inhibitors
are used successfully for treatment of disease. Typical drug development pipelines involve …

ER/K α-helices are a subset of single alpha helical domains, which exhibit unusual stability
as isolated protein secondary structures. They adopt an elongated structural conformation …

Cell migration is essential to embryonic development, wound healing, and cancer cell
dissemination. Cells move via leading-edge protrusion, substrate adhesion, and retraction of …

Resolving the conformational dynamics of large multidomain proteins has proven to be a
significant challenge. Here we use a variety of techniques to dissect the roles of individual …

Protein kinases achieve substrate selective phosphorylation through their conformational
flexibility and dynamic interaction with the substrate. Designing substrate selective or kinase …

Protein kinase Cα (PKCα) belongs to the family of AGC kinases that phosphorylate multiple
peptide substrates. Although the consensus sequence motif has been identified and used to …

Objectives Cell migration has a key role in cancer metastasis, which contributes to drug
resistance and tumour recurrence. Better understanding of the mechanisms involved in this …

IKBKE (IKK?) has emerged as a key modulator of multiple substrates, controlling oncogenic
pathways in various malignancies. mTOR signaling, required for cellular growth …

The mating-specific yeast Gα controls pheromone signaling by sequestering Gβγ and by
regulating the Fus3 MAP kinase. Disrupting Gα-Fus3 interaction leads to severe defects in …

Post-translational modifications (PTMs) are responsible for a variety of cellular processes.
One such PTM is protein phosphorylation, which is catalyzed by kinases. Kinase enzymes …