The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies

CA Juan, JM Pérez de la Lastra, FJ Plou… - International Journal of …, 2021 - mdpi.com
Living species are continuously subjected to all extrinsic forms of reactive oxidants and
others that are produced endogenously. There is extensive literature on the generation and …

[HTML][HTML] The double-edged roles of ROS in cancer prevention and therapy

Y Wang, H Qi, Y Liu, C Duan, X Liu, T Xia, D Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

[HTML][HTML] Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Tumor‐microenvironment‐responsive nanomedicine for enhanced cancer immunotherapy

S Peng, F Xiao, M Chen, H Gao - Advanced Science, 2022 - Wiley Online Library
The past decades have witnessed great progress in cancer immunotherapy, which has
profoundly revolutionized oncology, whereas low patient response rates and potential …

The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Copper uptake, essentiality, toxicity, detoxification and risk assessment in soil-plant environment

Z Shabbir, A Sardar, A Shabbir, G Abbas, S Shamshad… - Chemosphere, 2020 - Elsevier
Copper (Cu) is an essential metal for human, animals and plants, although it is also
potentially toxic above supra-optimal levels. In plants, Cu is an essential cofactor of …

Anti-angiogenic therapy: current challenges and future perspectives

F Lopes-Coelho, F Martins, SA Pereira… - International Journal of …, 2021 - mdpi.com
Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and
oxygen supply to the tumor cells through the decrease of the vascular network and the …

DNA damage/repair management in cancers

JF Alhmoud, JF Woolley… - Advances in Medical …, 2021 - api.taylorfrancis.com
DNA damage can alter nucleotide sequences and lead to expression of dysfunctional
proteins that impact normal cellular physiology. Sources of DNA damage can be …

Reactive oxygen species scavenging nanomedicine for the treatment of ischemic heart disease

Z Zhang, R Dalan, Z Hu, JW Wang… - Advanced …, 2022 - Wiley Online Library
Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …