Exercise Intolerance in Patients With Heart Failure: JACC State-of-the-Art Review
Exercise intolerance is the cardinal symptom of heart failure (HF) and is of crucial relevance,
because it is associated with a poor quality of life and increased mortality. While impaired …
because it is associated with a poor quality of life and increased mortality. While impaired …
Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors
K Lechner, C von Schacky… - European journal of …, 2020 - journals.sagepub.com
Despite major efforts to reduce atherosclerotic cardiovascular disease (ASCVD) burden with
conventional risk factor control, significant residual risk remains. Recent evidence on non …
conventional risk factor control, significant residual risk remains. Recent evidence on non …
Atherosclerosis and inflammation: insights from the theory of general pathological processes
E Gusev, A Sarapultsev - International Journal of Molecular Sciences, 2023 - mdpi.com
Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …
Age-induced accumulation of methylmalonic acid promotes tumour progression
The risk of cancer and associated mortality increases substantially in humans from the age
of 65 years onwards,,,,–. Nonetheless, our understanding of the complex relationship …
of 65 years onwards,,,,–. Nonetheless, our understanding of the complex relationship …
Nutrition management in older adults with diabetes: a review on the importance of shifting prevention strategies from metabolic syndrome to frailty
The increasing prevalence of older adults with diabetes has become a major social burden.
Diabetes, frailty, and cognitive dysfunction are closely related to the mechanisms of aging …
Diabetes, frailty, and cognitive dysfunction are closely related to the mechanisms of aging …
Connecting aging biology and inflammation in the omics era
KA Walker, N Basisty, DM Wilson… - The Journal of Clinical …, 2022 - Am Soc Clin Investig
Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …
architecture that triggers a proinflammatory state in blood and solid tissues, termed …
Inflammation and DNA damage: cause, effect or both
Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
Natural killer cell dysfunction and its role in COVID-19
When facing an acute viral infection, our immune systems need to function with finite
precision to enable the elimination of the pathogen, whilst protecting our bodies from …
precision to enable the elimination of the pathogen, whilst protecting our bodies from …
Skeletal muscle health and cognitive function: a narrative review
Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves
both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and …
both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and …
Frailty prevalence and impact on outcomes in patients with atrial fibrillation: a systematic review and meta-analysis of 1,187,000 patients
Frailty is a clinical syndrome characterized by a reduced physiologic reserve, increased
vulnerability to stressors and an increased risk of adverse outcomes. People with atrial …
vulnerability to stressors and an increased risk of adverse outcomes. People with atrial …