The effect of dietary polyphenols on vascular health and hypertension: current evidence and mechanisms of action
The aim of this review was to explore existing evidence from studies conducted on humans
and summarize the mechanisms of action of dietary polyphenols on vascular health, blood …
and summarize the mechanisms of action of dietary polyphenols on vascular health, blood …
Inflammaging: implications in sarcopenia
E Antuña, C Cachán-Vega, JC Bermejo-Millo… - International journal of …, 2022 - mdpi.com
In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …
Sensitive activatable nanoprobes for real‐time ratiometric magnetic resonance imaging of reactive oxygen species and ameliorating inflammation in vivo
X Li, Y Liu, X Qi, S Xiao, Z Xu, Z Yuan, Q Liu… - Advanced …, 2022 - Wiley Online Library
Imaging‐guided real‐time monitoring of the treatment process of inflammatory diseases is
important for the timely adjustment of treatment planning to lower unnecessary side effects …
important for the timely adjustment of treatment planning to lower unnecessary side effects …
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
Senescent cells, which accumulate in organisms over time, contribute to age-related tissue
decline. Genetic ablation of senescent cells can ameliorate various age-related pathologies …
decline. Genetic ablation of senescent cells can ameliorate various age-related pathologies …
Vascular endothelial cells and innate immunity
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …
participate in both innate and adaptive immune responses. We previously reported that, in …
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …
A hypothesis for pathobiology and treatment of COVID‐19: the centrality of ACE1/ACE2 imbalance
K Sriram, PA Insel - British journal of pharmacology, 2020 - Wiley Online Library
Angiotensin Converting Enzyme2 is the cell surface binding site for the coronavirus SARS‐
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …
Immunoporosis: role of innate immune cells in osteoporosis
Osteoporosis or porous bone disorder is the result of an imbalance in an otherwise highly
balanced physiological process known as 'bone remodeling'. The immune system is …
balanced physiological process known as 'bone remodeling'. The immune system is …
The interplay between immunosenescence and age-related diseases
F Barbé-Tuana, G Funchal, CRR Schmitz… - Seminars in …, 2020 - Springer
The aging immune system (immunosenescence) has been implicated with increased
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …
Single-cell analysis of human testis aging and correlation with elevated body mass index
X Nie, SK Munyoki, M Sukhwani, N Schmid, A Missel… - Developmental cell, 2022 - cell.com
Aging men display reduced reproductive health; however, testis aging is poorly understood
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …