Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications

J Xie, Y Wang, L Lu, L Liu, X Yu, F Pei - Ageing research reviews, 2021 - Elsevier
Cellular senescence is the inability of cells to proliferate, which has both beneficial and
detrimental effects on tissue development and homeostasis. Chronic accumulation of …

[HTML][HTML] Effects of dietary patterns on biomarkers of inflammation and immune responses: a systematic review and meta-analysis of randomized controlled trials

L Koelman, CE Rodrigues, K Aleksandrova - Advances in Nutrition, 2022 - Elsevier
Altered immune cell phenotype and chronic inflammation are key features shared by various
chronic diseases. Evidence from nutritional interventions aimed at alleviating inflammation …

COPD and multimorbidity: recognising and addressing a syndemic occurrence

LM Fabbri, BR Celli, A Agustí, GJ Criner… - The Lancet …, 2023 - thelancet.com
Most patients with chronic obstructive pulmonary disease (COPD) have at least one
additional, clinically relevant chronic disease. Those with the most severe airflow obstruction …

Plasma metabolites to profile pathways in noncommunicable disease multimorbidity

M Pietzner, ID Stewart, J Raffler, KT Khaw… - Nature medicine, 2021 - nature.com
Multimorbidity, the simultaneous presence of multiple chronic conditions, is an increasing
global health problem and research into its determinants is of high priority. We used …

Molecular mechanisms of inflammation in sarcopenia: diagnosis and therapeutic update

GE Jimenez-Gutierrez, LE Martínez-Gómez… - Cells, 2022 - mdpi.com
Sarcopenia is generally an age-related condition that directly impacts the quality of life. It is
also related to chronic diseases such as metabolic dysfunction associated with diabetes and …

Immunosenescence, inflammaging, and frailty: role of myeloid cells in age-related diseases

A Bleve, F Motta, B Durante, C Pandolfo… - Clinical reviews in …, 2022 - Springer
The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …

Skeletal muscle oxidative stress and inflammation in aging: Focus on antioxidant and anti-inflammatory therapy

M Chen, Y Wang, S Deng, Z Lian, K Yu - Frontiers in Cell and …, 2022 - frontiersin.org
With aging, the progressive loss of skeletal muscle will have negative effect on multiple
physiological parameters, such as exercise, respiration, thermoregulation, and metabolic …

Preeclampsia pathophysiology and adverse outcomes during pregnancy and postpartum

C Bisson, S Dautel, E Patel, S Suresh, P Dauer… - Frontiers in …, 2023 - frontiersin.org
Background Preeclampsia is a disease with far-reaching consequences that extend beyond
the immediate postpartum period and have a significant impact later in life. Preeclampsia …

Plasmalogens and chronic inflammatory diseases

JC Bozelli Jr, S Azher, RM Epand - Frontiers in physiology, 2021 - frontiersin.org
It is becoming widely acknowledged that lipids play key roles in cellular function, regulating
a variety of biological processes. Lately, a subclass of glycerophospholipids, namely …

N-Acetylcysteine: A potential therapeutic agent for SARS-CoV-2

FL Poe, J Corn - Medical hypotheses, 2020 - Elsevier
COVID-19, a respiratory disease caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), continues to spread across the globe. Predisposing factors such as age …