Background: Ursolic acid (UA) is a natural pentacyclic triterpene derived from fruit, herb, and
other plants. UA can act on molecular targets of various signaling pathways, inhibit the …

Nanoparticles (NPs) based on the proteolytic enzyme trypsin (TRY) were prepared by a
biocompatible methodology. TRY co-assembled with the anionic polysaccharide chondroitin …

A peculiar polygonal protein scaffolding that resembles to spectrin-based skeleton of red
blood cells can be reconstructed on the outer surface of vesicle-like nanoerythrosomes. The …

Nanoparticles having a radius of ca. 200 nm are prepared from the proteolytic enzyme
trypsin (TRY) and the anionic polysaccharide chondroitin sulfate (CS) by electrostatic …

Protein structure defines protein function and plays an extremely important role in protein
characterization. Recently, two groups of researchers from DeepMind and the Baker lab …

Inspired by biology, great progress has been made in creating artificial molecular motors.
However, the dream of harnessing proteins-the building blocks selected by Nature-to design …

Background Coelomic fluid, a pharmacologically active compound in earthworms, exhibits a
range of biological activities, including antioxidant, anti-inflammatory, and anticancer …

It was found that the enzymes of the coagulation cascade interact with lipid microparticles or
microvesicles of natural or artificial origin that circulate in the blood. Such interactions can …

Установлено, что ферменты каскада коагуляции взаимодействуют с липидными
микрочастицами или микровезикулами природного или искусственного происхождения …

The first topic of this thesis (Chapter 2) presents a mutational study performed on 17β-
hydroxysteroid dehydrogenase type 14 (17β-HSD14) S205 variant. Five different mutations …