Synthesis of novel 5-(2, 5-bis (2, 2, 2-trifluoroethoxy) phenyl)-1, 3, 4-oxadiazole-2-thiol derivatives as potential glucosidase inhibitors
Background A hybrid molecule of different biologically active substances can improve affinity
and efficiency compared to a standard drug. Hence based on this fact, we predict that a …
and efficiency compared to a standard drug. Hence based on this fact, we predict that a …
Recent advancements in triazole-based click chemistry in cancer drug discovery and development
Thieme E-Journals - SynOpen / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SynOpen Full-text search Full-text search Author …
Service Library Service Help Contact Portal SynOpen Full-text search Full-text search Author …
Optimization of pyrazole-based compounds with 1, 2, 4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis …
The cardiovascular side effects associated with COX-2 selective drugs were the worst for
coxibs leading to their withdrawal from the market a few years after their discovery …
coxibs leading to their withdrawal from the market a few years after their discovery …
[HTML][HTML] 1, 5-disubstituted-1, 2, 3-triazoles counteract mitochondrial dysfunction acting on F1FO-ATPase in models of cardiovascular diseases
C Algieri, C Bernardini, S Marchi, M Forte… - Pharmacological …, 2023 - Elsevier
The compromised viability and function of cardiovascular cells are rescued by small
molecules of triazole derivatives (Tzs), identified as 3a and 3b, by preventing mitochondrial …
molecules of triazole derivatives (Tzs), identified as 3a and 3b, by preventing mitochondrial …
Synthesis and antimicrobial activity of new heteroaryl (aryl) thiazole derivatives molecular docking studies
V Kartsev, A Geronikaki, A Zubenko, A Petrou… - Antibiotics, 2022 - mdpi.com
Herein, we report the design, synthesis, and evaluation of the antimicrobial activity of new
heteroaryl (aryl) thiazole derivatives. The design was based on a molecular hybridization …
heteroaryl (aryl) thiazole derivatives. The design was based on a molecular hybridization …
New horizons in benzothiazole scaffold for cancer therapy: Advances in bioactivity, functionality, and chemistry
In the pasture of oncology, anticancer agents having advanced modes of action are of great
interest because of increasing chronicity of resistance against anticancer drugs. Heterocyclic …
interest because of increasing chronicity of resistance against anticancer drugs. Heterocyclic …
Synthesis of pharmacological relevant 1, 2, 3-triazole and its analogues-A review
R Varala, HB Bollikolla… - Current Organic …, 2021 - ingentaconnect.com
In this review, authors focus mostly on the various synthetic strategies developed so far for 1,
2, 3-triazole scaffold and its derivatives via different approaches such as metal-free, metal …
2, 3-triazole scaffold and its derivatives via different approaches such as metal-free, metal …
A review of antimalarial activity of two or three nitrogen atoms containing heterocyclic compounds
Malaria, a nocuous disease, which has become a major challenge for the health resulting in
deaths of millions of people around the globe. Malaria is a parasitic disease propagated by …
deaths of millions of people around the globe. Malaria is a parasitic disease propagated by …
A comprehensive review on triazole based conjugates as acetylcholinesterase inhibitors: Design strategies, synthesis, biological activity, structure activity …
Significant advancements have been made in development of Acetylcholinesterase
inhibitors as Anti-Alzheimer drugs. Triazoles, a 5-membered heterocyclic nucleus containing …
inhibitors as Anti-Alzheimer drugs. Triazoles, a 5-membered heterocyclic nucleus containing …
Phytochemical Constituents of Adansonia digitata L. (Baobab) Fruit Pulp from Tekeze Valley, Tigrai, Ethiopia
Baobab (Adansonia digitata L) is a large tree species growing in semiarid and arid lowlands
of Ethiopia and other places. The plant is valued by natives for its contributions as a cash …
of Ethiopia and other places. The plant is valued by natives for its contributions as a cash …