Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

Carbazole 1 was isolated first from coal tar in 1872 by Graebe and Glazer (Figure 1). 1 In
1965, Chakraborty et al. described the isolation and antibiotic properties of murrayanine …

Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …

Stepwise differentiation from embryonic stem cells (ESCs) to functional insulin-secreting
beta cells will identify key steps in beta-cell development and may yet prove useful for …

Vitamin E was originally considered a dietary factor of animal nutrition especially important
for normal reproduction. The significance of vitamin E has been subsequently proven as a …

Abstract KDR/Flk-1 tyrosine kinase, one of the two VEGF receptors induces mitogenesis and
differentiation of vascular endothelial cells. We have previously reported that a major target …

Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Various inhibitors were tested for their potential to suppress the kinase activity of protein
kinase C μ (PKCμ) in vitro and in vivo. Among the staurosporine-derived, rather selective …