FLT3-selective PROTAC: Enhanced safety and increased synergy with Venetoclax in FLT3-ITD mutated acute myeloid leukemia
Y Tan, L Xin, Q Wang, R Xu, X Tong, G Chen, L Ma… - Cancer letters, 2024 - Elsevier
Acute myeloid leukemia (AML) patients carrying Fms-like tyrosine kinase 3-internal tandem
duplication (FLT3-ITD) mutations often face a poor prognosis. While some FLT3 inhibitors …
duplication (FLT3-ITD) mutations often face a poor prognosis. While some FLT3 inhibitors …
Understanding the Role of Activation Loop Mutants in Drug Efficacy for FLT3-ITD
JU Kazi, L Al Ashiri, R Purohit, L Rönnstrand - Cancers, 2023 - mdpi.com
Simple Summary In this study, we investigated FLT3, a protein that plays a vital role in the
development of early blood cells. FLT3 often undergoes changes that contribute to the onset …
development of early blood cells. FLT3 often undergoes changes that contribute to the onset …
Understanding the characteristic behavior of the wild-type and mutant protein structure of FLT3 protein by computational methods
FLT3 emerges as a commonly mutated protein with significant prognostic implications in
acute myeloid leukemia (AML). Point mutations or deletions in the tyrosine kinase domain …
acute myeloid leukemia (AML). Point mutations or deletions in the tyrosine kinase domain …
FLT3-ITD-Specific PROTAC:: Enhanced Safety and Increased Synergy with Venetoclax in Acute Myeloid Leukemia
Y Tan, L Xin, Q Wang, R Xu, X Tong, G Chen, L Ma… - 2023 - papers.ssrn.com
Background: Acute myeloid leukemia (AML) patients carrying Fms-like tyrosine kinase 3-
internal tandem duplication (FLT3-ITD) mutations often face a poor prognosis. While some …
internal tandem duplication (FLT3-ITD) mutations often face a poor prognosis. While some …