Bloodstream infections in critically ill patients: an expert statement

JF Timsit, E Ruppé, F Barbier, A Tabah… - Intensive care medicine, 2020 - Springer
Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Diagnosis and treatment of invasive candidiasis

N Barantsevich, E Barantsevich - Antibiotics, 2022 - mdpi.com
Candida species, belonging to commensal microbial communities in humans, cause
opportunistic infections in individuals with impaired immunity. Pathogens encountered in …

EORTC/MSGERC definitions of invasive fungal diseases: summary of activities of the intensive care unit working group

M Bassetti, E Azoulay, BJ Kullberg… - Clinical Infectious …, 2021 - academic.oup.com
The EORTC/MSGERC recently revised and updated the consensus definitions of invasive
fungal disease (IFD). These definitions primarily focus on patients with cancer and stem cell …

Initial antimicrobial management of sepsis

MS Niederman, RM Baron, L Bouadma, T Calandra… - Critical care, 2021 - Springer
Sepsis is a common consequence of infection, associated with a mortality rate> 25%.
Although community-acquired sepsis is more common, hospital-acquired infection is more …

Timing of antibiotic therapy in the ICU

MH Kollef, AF Shorr, M Bassetti, JF Timsit, ST Micek… - Critical Care, 2021 - Springer
Severe or life threatening infections are common among patients in the intensive care unit
(ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial …

Antifungal drug resistance: an emergent health threat

A Vitiello, F Ferrara, M Boccellino, A Ponzo, C Cimmino… - Biomedicines, 2023 - mdpi.com
Fungal infections, named mycosis, can cause severe invasive and systemic diseases that
can even lead to death. In recent years, epidemiological data have recorded an increase in …

Invasive candidiasis in critical care: challenges and future directions

C Logan, I Martin-Loeches, T Bicanic - Intensive care medicine, 2020 - Springer
Invasive candidiasis is the most common critical care-associated fungal infection with a
crude mortality of~ 40–55%. Important factors contributing to risk of invasive candidiasis in …

(1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial

F Bloos, J Held, S Kluge, P Simon, K Kogelmann… - Intensive care …, 2022 - Springer
Purpose To investigate whether (1→ 3)-β-d-Glucan (BDG)-guidance shortens time to
antifungal therapy and thereby reduces mortality of sepsis patients with high risk of invasive …

Epidemiology of Candidemia and Fluconazole Resistance in an ICU before and during the COVID-19 Pandemic Era

C Routsi, J Meletiadis, E Charitidou, A Gkoufa… - Antibiotics, 2022 - mdpi.com
The objectives of this study were to investigate the incidence of candidemia, as well as the
factors associated with Candida species distribution and fluconazole resistance, among …

ICU-acquired infections in immunocompromised patients

L Kreitmann, J Helms, I Martin-Loeches, J Salluh… - Intensive Care …, 2024 - Springer
Immunocompromised patients account for an increasing proportion of the typical intensive
care unit (ICU) case-mix. Because of the increased availability of new drugs for cancer and …