Biological organisms learn from interactions with their environment throughout their lifetime.
For artificial systems to successfully act and adapt in the real world, it is desirable to similarly …

Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

Replay is the reactivation of one or more neural patterns that are similar to the activation
patterns experienced during past waking experiences. Replay was first observed in …

Artificial neural networks are known to suffer from catastrophic forgetting: when learning
multiple tasks sequentially, they perform well on the most recent task at the expense of …

During non-rapid eye movement (NREM) sleep, neuronal populations in the mammalian
forebrain alternate between periods of spiking and inactivity. Termed the slow oscillation in …

Objective sleep quality can be measured by electroencephalography (EEG), a non-invasive
technique to quantify electrical activity generated by the brain. With EEG, sleep depth is …

Sleep plays an important role in the consolidation of recent memories. However, the cellular
and synaptic mechanisms of consolidation during sleep remain poorly understood. In this …

Highlights•A mechanism for NREM-mediated homeostatic function is proposed.•The
mechanism relies on sequential activity at the DOWN→ UP transition.•Spiking from high-to …

The link between the combined action of neuromodulators in the brain and global brain
states remains a mystery. In this study, using biophysically realistic models of the …

The high prevalence of sleep disturbance in neurodegenerative and psychiatric conditions
is often interpreted as evidence for both sleep's sensitivity to and causal involvement in brain …