In metabolic conditions such as obesity and diabetes, which are associated with
deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation …

Cancer immunotherapy has made impressive advances in improving the outcome of
patients affected by malignant diseases. Nonetheless, some limitations still need to be …

TRF1 is an essential component of the telomeric protective complex or shelterin. We
previously showed that dysfunctional telomeres in alveolar type II (ATII) cells lead to …

Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Tumor progression
depends on interactions of cancer cells with the tumor microenvironment. Here, we find …

CPT-11 is one of the drugs employed in colorectal cancer treatment and has faced
challenges in the form of resistance. The insulin-like growth factor 1 receptor is a tyrosine …

Background Lung cancer is the most common and deadliest cancer worldwide, and
approximately 90% of all lung cancer deaths are caused by tumor metastasis. Tumor …

Osteosarcoma, the most common bone malignancy in children and adolescents, poses
considerable challenges in terms of prognosis, especially for patients with metastatic or …

An emerging view regarding cancer-associated fibroblast (CAF) is that it plays a critical role
in tumorigenesis and immunosuppression in the tumor microenvironment (TME), but the …

Simple Summary Metastasis is the root cause of cancer death, responsible for roughly 90%
of all cancer-related fatalities. Therefore, treating metastatic cancer is essential for optimal …

Tumor metastasis requires systemic remodeling of distant organ microenvironments that
impacts immune cell phenotypes, population structure, and intercellular communication …