Optogenetic stimulation of primary motor cortex regulates beta oscillations in the basal ganglia: A Computational study

Y Yu, Y Fan, S Hou, Q Wang - Communications in Nonlinear Science and …, 2023 - Elsevier
The primary motor cortex (M1) contains interconnected and diverse layers that play an
important role in motor execution. In recent years, M1 has emerged as one of the hot targets …

Deep Brain Stimulation with a Computational Model for the Cortex‐Thalamus‐Basal‐Ganglia System and Network Dynamics of Neurological Disorders

H Shaheen, R Melnik - Computational and Mathematical …, 2022 - Wiley Online Library
Deep brain stimulation (DBS) can alleviate the movement disorders like Parkinson's disease
(PD). Indeed, it is known that aberrant beta (13‐30 Hz) oscillations and the loss of …

Virtual brain twins: from basic neuroscience to clinical use

HE Wang, P Triebkorn, M Breyton… - National Science …, 2024 - academic.oup.com
Virtual brain twins are personalized, generative and adaptive brain models based on data
from an individual's brain for scientific and clinical use. After a description of the key …

Regulating absence seizures by tri-phase delay stimulation applied to globus pallidus internal

S Hou, D Fan, Q Wang - Applied Mathematics and Mechanics, 2022 - Springer
In this paper, a reduced globus pallidus internal (GPI)-corticothalamic (GCT) model is
developed, and a tri-phase delay stimulation (TPDS) with sequentially applying three pulses …

[HTML][HTML] Multiscale co-simulation of deep brain stimulation with brain networks in neurodegenerative disorders

H Shaheen, S Pal, R Melnik - Brain Multiphysics, 2022 - Elsevier
Deep brain stimulation (DBS) has been used successfully as symptomatic treatment in
several neurodegenerative disorders, including Parkinson's disease (PD). However, the …

Optogenetic generation of neural firing patterns with temporal shaping of light pulses

H Bansal, G Pyari, S Roy - Photonics, 2023 - mdpi.com
The fundamental process of information processing and memory formation in the brain is
associated with complex neuron firing patterns, which can occur spontaneously or be …

Modeling neurotransmission: Computational tools to investigate neurological disorders

D Gandolfi, GM Boiani, A Bigiani, J Mapelli - International Journal of …, 2021 - mdpi.com
The investigation of synaptic functions remains one of the most fascinating challenges in the
field of neuroscience and a large number of experimental methods have been tuned to …

Double-edged effect of astrocyte in the transition of physiopathological states in Parkinson's disease

Z Cao, L Du, H Zhang, Z Shen, Z Deng - Chaos, Solitons & Fractals, 2024 - Elsevier
Understanding the astrocytic effect in the cortical-basal ganglia-thalamus circuit can offer
new insights into the generation mechanisms and therapeutics of Parkinson's disease (PD) …

Control of epileptic activities in a cortex network of multiple coupled neural populations under electromagnetic induction

Z Sun, Y Liu, X Yang, W Xu - Applied Mathematics and Mechanics, 2023 - Springer
Epilepsy is believed to be associated with the abnormal synchronous neuronal activity in the
brain, which results from large groups or circuits of neurons. In this paper, we choose to …

Rhythmicity and firing modes in modular neuronal network under electromagnetic field

Y Liu, Z Sun, X Yang, W Xu - Nonlinear Dynamics, 2021 - Springer
Based on a modified Hindmarsh–Rose model with electromagnetic induction being
considered, rhythmicity and firing modes in modular neural network consisting of …