Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Appetite and body weight regulation are controlled by the central nervous system (CNS) in a
rather complicated manner. The human brain plays a central role in integrating internal and …

The lack of adequate physical activity and obesity created a worldwide pandemic. Obesity is
characterized by the deposition of adipose tissue in various parts of the body; it is now …

Problem Despite progress in immunobiology, pre‐eclampsia (PE) remains one of the most
common reasons for women to die during pregnancy. The widespread pathophysiological …

Receptors of leptin, the prototypical adipokine, are expressed throughout the cortex and
several other areas of the brain. Although typically studied for its role in energy intake and …

The hypothalamic-pituitary-thyroid (HPT) axis plays a critical role in mediating changes in
metabolism and thermogenesis. Thus, the central regulation of the thyroid axis by …

Lipodystrophy patients are hypoleptinemic and insulin resistant. Women have enlarged
polycystic ovaries, hyperandrogenism, and amenorrhea. We have determined the role of …

To evaluate the impact of body mass index (BMI)(weight (kg)/height (m) 2) and change in
body silhouette on asthma risk, the authors investigated a cohort of women participating in …

The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood, and
experimental models are an alternative to study this issue. We investigated the effects of a …

Metabolic syndrome (MS) increases cardiovascular risk. The role of thyroid hormone on
components of MS is unclear. We analyzed a sample of 4733 euthyroid subjects from …