1.1. Methodology and Evidence Review The recommendations listed in this document are,
whenever possible, evidence based. The current document constitutes a full revision and …

Thrombosis is the most important underlying mechanism of coronary artery disease and
embolic stroke. Hence, antithrombotic therapy is widely used in these scenarios. However …

Cardiovascular diseases are the major cause of mortality and morbidity in the industrialized
world, while their incidents are on fast ascendancy in developing countries. 1 According to …

Abstract β‐Secretase cleavage represents the first step in the generation of Aβ polypeptides
and initiates the amyloid cascade that leads to neurodegeneration in Alzheimer's disease …

BACKGROUND: Current fibrinolytic therapies fail to achieve optimum reperfusion in many
patients. Low-molecular-weight heparins and platelet glycoprotein IIb/IIIa inhibitors have …

1.1. Methodology and Evidence Review The recommendations listed in this document are,
whenever possible, evidence based. The current document constitutes a full revision and …

Vascular endothelial cells are thought to be the main source of plasma tissue-type
plasminogen activator (t-PA) and von Willebrand factor (VWF). Previous studies have …

Background: Administration of L-carnitine in patients with anterior acute myocardial
infarction (AMI) prevents left ventricular remodeling. Current study was aimed to assess the …

Background—Protease nexin-1 (PN-1) is a serpin that inhibits plasminogen activators,
plasmin, and thrombin. PN-1 is barely detectable in plasma, but we have shown recently that …

Background: Current thrombolytic therapies utilize exogenous plasminogen activators (PAs)
to effectively lyse clots, restoring blood flow, and preventing tissue and organ death. These …