[HTML][HTML] High-grade prostatic intraepithelial neoplasia
DG Bostwick, J Qian - Modern pathology, 2004 - Elsevier
High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely
preinvasive stage of adenocarcinoma, almost two decades after its first formal description …
preinvasive stage of adenocarcinoma, almost two decades after its first formal description …
Precursors of prostate cancer
DG Bostwick, L Cheng - Histopathology, 2012 - Wiley Online Library
Bostwick DG & Cheng L (2012) Histopathology 60, 4–27 Precursors of prostate cancer High‐
grade prostatic intraepithelial neoplasia (PIN) is the only accepted precursor of prostatic …
grade prostatic intraepithelial neoplasia (PIN) is the only accepted precursor of prostatic …
Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer
New predictive markers for managing prostate cancer are urgently required because of the
highly variable natural history of this disease. At the time of diagnosis, Gleason score …
highly variable natural history of this disease. At the time of diagnosis, Gleason score …
Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development: recommendations of the American association for …
JA O'Shaughnessy, GJ Kelloff, GB Gordon… - Clinical Cancer …, 2002 - AACR
Precancer or intraepithelial neoplasia (IEN) is a noninvasive lesion that has genetic
abnormalities, loss of cellular control functions, and some phenotypic characteristics of …
abnormalities, loss of cellular control functions, and some phenotypic characteristics of …
A quantitative promoter methylation profile of prostate cancer
Purpose: Promoter hypermethylation is an alternative pathway for gene silencing in
neoplastic cells and a promising cancer detection marker. Although quantitative methylation …
neoplastic cells and a promising cancer detection marker. Although quantitative methylation …
TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas, paired HGPIN lesions
N Cerveira, FR Ribeiro, A Peixoto, V Costa, R Henrique… - Neoplasia, 2006 - Elsevier
TMPRSS2-ETS gene fusions have been found recurrently in prostate carcinomas, but not in
the presumed precursor lesion, high-grade prostatic intraepithelial neoplasia (HGPIN) …
the presumed precursor lesion, high-grade prostatic intraepithelial neoplasia (HGPIN) …
Differential expression of the estrogen receptor beta (ERβ) in human prostate tissue, premalignant changes, and in primary, metastatic, and recurrent prostatic …
T Fixemer, K Remberger, H Bonkhoff - The Prostate, 2003 - Wiley Online Library
BACKGROUND Estrogen signaling mediated by the estrogen receptor beta (ERβ) has
potential implications in normal and abnormal prostate growth. Few studies have addressed …
potential implications in normal and abnormal prostate growth. Few studies have addressed …
Synthesis and antiproliferative activity of 2-aryl-4-oxo-thiazolidin-3-yl-amides for prostate cancer
We have previously described serine amide phosphates (SAPs) as a novel class of cytotoxic
agents for prostate cancer. Several of them showed potent cytotoxicity against human …
agents for prostate cancer. Several of them showed potent cytotoxicity against human …
Complex patterns of ETS gene alteration arise during cancer development in the human prostate
An ERG gene 'break-apart'fluorescence in situ hybridization (FISH) assay has been used to
screen whole-mount prostatectomy specimens for rearrangements at the ERG locus. In …
screen whole-mount prostatectomy specimens for rearrangements at the ERG locus. In …
The Retinoic Acid Synthesis Gene ALDH1a2 Is a Candidate Tumor Suppressor in Prostate Cancer
H Kim, J Lapointe, G Kaygusuz, DE Ong, C Li… - Cancer research, 2005 - AACR
Prostate cancer is the most common cancer among men in the United States, and aberrant
DNA methylation is known to be an early molecular event in its development. Here, we have …
DNA methylation is known to be an early molecular event in its development. Here, we have …