Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation

PH Vachon - Journal of signal transduction, 2011 - Wiley Online Library
Cell survival and apoptosis implicate an increasing complexity of players and signaling
pathways which regulate not only the decision‐making process of surviving (or dying), but …

Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state‐specific uncoupling with the PI3‐K/Akt‐1 and MEK/Erk pathways

V Bouchard, MJ Demers, S Thibodeau… - Journal of cellular …, 2007 - Wiley Online Library
Human intestinal epithelial cell survival and anoikis are distinctively regulated according to
the state of differentiation. In the present study, we analyzed the roles of focal adhesion …

β1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms

V Bouchard, C Harnois, MJ Demers, S Thibodeau… - Apoptosis, 2008 - Springer
The molecular determinants which dictate survival and apoptosis/anoikis in human intestinal
crypt cells remain to be fully understood. To this effect, the roles of β1 integrin/Fak/Src …

Intestinal epithelial cancer cell anoikis resistance: EGFR‐mediated sustained activation of Src overrides Fak‐dependent signaling to MEK/Erk and/or PI3‐K/Akt‐1

MJ Demers, S Thibodeau, D Noël… - Journal of cellular …, 2009 - Wiley Online Library
Herein, we investigated the survival roles of Fak, Src, MEK/Erk, and PI3‐K/Akt‐1 in intestinal
epithelial cancer cells (HCT116, HT29, and T84), in comparison to undifferentiated and …

[HTML][HTML] Progress in researches about focal adhesion kinase in gastrointestinal tract

HF Hao, Y Naomoto, XH Bao, N Watanabe… - World Journal of …, 2009 - ncbi.nlm.nih.gov
Focal adhesion kinase (FAK) is a 125-kDa non-receptor protein tyrosine. Growth factors or
the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in …

Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes

M Beauséjour, D Noël, S Thibodeau, V Bouchard… - Apoptosis, 2012 - Springer
In human intestinal epithelial crypt (HIEC) cells, the PI3-K/Akt-1 pathway is crucial for the
promotion of cell survival and suppression of anoikis. Class I PI3-K consists of a complex …

Glycaemic control in diabetic rats treated with islet transplantation using plasma combined with hydroxypropylmethyl cellulose hydrogel

A Schaschkow, S Sigrist, C Mura, J Barthes, NE Vrana… - Acta Biomaterialia, 2020 - Elsevier
Islet transplantation is one of the most efficient cell therapies used in clinics and could treat a
large proportion of patients with diabetes. However, it is limited by the high requirement of …

Suppression of anoikis in human intestinal epithelial cells: differentiation state-selective roles of α2β1, α3β1, α5β1, and α6β4 integrins

M Beauséjour, S Thibodeau, MJ Demers, V Bouchard… - BMC Cell Biology, 2013 - Springer
Background Regulation of anoikis in human intestinal epithelial cells (IECs) implicates
differentiation state-specific mechanisms. Human IECs express distinct repertoires of …

Up-regulation of Tropomyosin related kinase B contributes to resistance to detachment-induced apoptosis in hepatoma multicellular aggregations

Z Zhang, L Han, Y Liu, X Liang, W Sun - Molecular biology reports, 2009 - Springer
To elucidate the molecular mechanisms of resistance to detachment-induced apoptosis, we
cultured BEL7402 hepatoma cells on plates coated with poly (2-hydroxyethyl methacrylate) …

Anoikis Regulation Complexities Distinctions and Cell Differentiation

M Beauséjour, A Boutin… - Apoptosis and Beyond: The …, 2018 - books.google.com
AJ adherens junction Akt (PKB) Ak mouse strain thymoma (protein kinase B) Apaf-1
apoptosis protease activating factor-1 ASK-1 apoptosis signal-regulating kinase-1 Bad Bcl-2 …