Cell survival and apoptosis implicate an increasing complexity of players and signaling
pathways which regulate not only the decision‐making process of surviving (or dying), but …

Human intestinal epithelial cell survival and anoikis are distinctively regulated according to
the state of differentiation. In the present study, we analyzed the roles of focal adhesion …

The molecular determinants which dictate survival and apoptosis/anoikis in human intestinal
crypt cells remain to be fully understood. To this effect, the roles of β1 integrin/Fak/Src …

Herein, we investigated the survival roles of Fak, Src, MEK/Erk, and PI3‐K/Akt‐1 in intestinal
epithelial cancer cells (HCT116, HT29, and T84), in comparison to undifferentiated and …

Focal adhesion kinase (FAK) is a 125-kDa non-receptor protein tyrosine. Growth factors or
the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in …

In human intestinal epithelial crypt (HIEC) cells, the PI3-K/Akt-1 pathway is crucial for the
promotion of cell survival and suppression of anoikis. Class I PI3-K consists of a complex …

Islet transplantation is one of the most efficient cell therapies used in clinics and could treat a
large proportion of patients with diabetes. However, it is limited by the high requirement of …

Background Regulation of anoikis in human intestinal epithelial cells (IECs) implicates
differentiation state-specific mechanisms. Human IECs express distinct repertoires of …

To elucidate the molecular mechanisms of resistance to detachment-induced apoptosis, we
cultured BEL7402 hepatoma cells on plates coated with poly (2-hydroxyethyl methacrylate) …

AJ adherens junction Akt (PKB) Ak mouse strain thymoma (protein kinase B) Apaf-1
apoptosis protease activating factor-1 ASK-1 apoptosis signal-regulating kinase-1 Bad Bcl-2 …