RAS family variants—most of which involve KRAS—are the most commonly occurring
hotspot mutations in human cancers and are associated with a poor prognosis. For almost …

Originally identified in Drosophila melanogaster in 1995, the Hippo signaling pathway plays
a pivotal role in organ size control and tumor suppression by inhibiting proliferation and …

Primary/intrinsic and treatment-induced acquired resistance limit the initial response rate to
and long-term efficacy of direct inhibitors of the KRASG12C mutant in cancer. To identify …

To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein
kinases support mutant KRAS–driven cancer growth, we determined the ERK-dependent …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that lacks effective
treatment options, highlighting the need for developing new therapeutic interventions. Here …

The Hippo signaling pathway is commonly dysregulated in human cancer, which leads to a
powerful tumor dependency on the YAP/TAZ transcriptional coactivators. Here, we used …

Simple Summary This work investigated the impact of Hippo signaling pathways in the
development of ovarian cancer. In order to investigate, the signatures relevant to Hippo …

The development of direct inhibitors of KRASG12C represents a monumental step forward in
the field of oncology. Nevertheless, there is considerable opportunity to enhance response …

Background Intervertebral disc degeneration (IDD) is a common musculoskeletal
degenerative disease, which often leads to low back pain and even disability, resulting in …

The PI3K signaling pathway plays an essential role in cancer cell proliferation and survival.
PI3K pathway inhibitors are now FDA-approved as a single agent treatment or in …