B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome
B cells are a major component of the tumour microenvironment, where they are
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …
B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity
CM Laumont, BH Nelson - Cancer Cell, 2023 - cell.com
Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …
[HTML][HTML] Interpretable deep learning model to predict the molecular classification of endometrial cancer from haematoxylin and eosin-stained whole-slide images: a …
Background Endometrial cancer can be molecularly classified into POLE mut, mismatch
repair deficient (MMRd), p53 abnormal (p53abn), and no specific molecular profile (NSMP) …
repair deficient (MMRd), p53 abnormal (p53abn), and no specific molecular profile (NSMP) …
Refining adjuvant treatment in endometrial cancer based on molecular features: the RAINBO clinical trial program
RAINBO Research Consortium - International Journal of …, 2023 - ijgc.bmj.com
Background The endometrial cancer molecular classification has been integrated into the
2020 World Health Organization (WHO) diagnostic classification and European treatment …
2020 World Health Organization (WHO) diagnostic classification and European treatment …
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment
G Cao, J Yue, Y Ruan, Y Han, Y Zhi, J Lu, M Liu… - The EMBO …, 2023 - embopress.org
The tumor microenvironment (TME) directly determines patients' outcomes and therapeutic
efficiencies. An in‐depth understanding of the TME is required to improve the prognosis of …
efficiencies. An in‐depth understanding of the TME is required to improve the prognosis of …
Mature dendritic cells enriched in immunoregulatory molecules (mregDCs): a novel population in the tumour microenvironment and immunotherapy target
J Li, J Zhou, H Huang, J Jiang… - Clinical and …, 2023 - Wiley Online Library
Abstract Background Dendritic cells (DCs) mediate divergent immune effects by activating T
cells or negatively regulating the immune response to promote immune tolerance. They …
cells or negatively regulating the immune response to promote immune tolerance. They …
The prognostic value and molecular properties of tertiary lymphoid structures in oesophageal squamous cell carcinoma
Y Ling, J Zhong, Z Weng, G Lin, C Liu… - Clinical and …, 2022 - Wiley Online Library
Abstract Background Tertiary lymphoid structures (TLSs) play key roles in tumour adaptive
immunity. However, the prognostic value and molecular properties of TLSs in oesophageal …
immunity. However, the prognostic value and molecular properties of TLSs in oesophageal …
[HTML][HTML] Tertiary lymphoid structures are critical for cancer prognosis and therapeutic response
Q Zhang, S Wu - Frontiers in Immunology, 2023 - frontiersin.org
Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates that form at sites of
chronic inflammation, including cancers, in non-lymphoid tissues. Although the formation of …
chronic inflammation, including cancers, in non-lymphoid tissues. Although the formation of …
[HTML][HTML] NeST: nested hierarchical structure identification in spatial transcriptomic data
Spatial gene expression in tissue is characterized by regions in which particular genes are
enriched or depleted. Frequently, these regions contain nested inside them subregions with …
enriched or depleted. Frequently, these regions contain nested inside them subregions with …
[HTML][HTML] Biomarkers of tumor-reactive CD4+ and CD8+ TILs associate with improved prognosis in endometrial cancer.
J Palomero, C Panisello… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Despite the growing interest in immunotherapeutic interventions for endometrial
cancer (EC), the prevalence, phenotype, specificity and prognostic value of tumor infiltrating …
cancer (EC), the prevalence, phenotype, specificity and prognostic value of tumor infiltrating …