B cells are a major component of the tumour microenvironment, where they are
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …

Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

Background Endometrial cancer can be molecularly classified into POLE mut, mismatch
repair deficient (MMRd), p53 abnormal (p53abn), and no specific molecular profile (NSMP) …

Background The endometrial cancer molecular classification has been integrated into the
2020 World Health Organization (WHO) diagnostic classification and European treatment …

The tumor microenvironment (TME) directly determines patients' outcomes and therapeutic
efficiencies. An in‐depth understanding of the TME is required to improve the prognosis of …

Abstract Background Dendritic cells (DCs) mediate divergent immune effects by activating T
cells or negatively regulating the immune response to promote immune tolerance. They …

Abstract Background Tertiary lymphoid structures (TLSs) play key roles in tumour adaptive
immunity. However, the prognostic value and molecular properties of TLSs in oesophageal …

Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates that form at sites of
chronic inflammation, including cancers, in non-lymphoid tissues. Although the formation of …

Spatial gene expression in tissue is characterized by regions in which particular genes are
enriched or depleted. Frequently, these regions contain nested inside them subregions with …

Background Despite the growing interest in immunotherapeutic interventions for endometrial
cancer (EC), the prevalence, phenotype, specificity and prognostic value of tumor infiltrating …