[HTML][HTML] Tear fluid hyperosmolality increases nerve impulse activity of cold thermoreceptor endings of the cornea

A Parra, O Gonzalez-Gonzalez, J Gallar, C Belmonte - PAIN®, 2014 - Elsevier
Dry eye disease (DED) is a multifactorial disorder affecting the composition and volume of
tears. DED causes ocular surface dryness, cooling, and hyperosmolality, leading ultimately …

Mechanical transduction by rat dorsal root ganglion neurons in vitro

GC McCarter, DB Reichling, JD Levine - Neuroscience letters, 1999 - Elsevier
Although it is generally presumed that mechanical sensitivity of somatosensory nerve fibers
results from the activation of mechanosensitive ion channels, a mechanically-gated whole …

Abnormal activity of corneal cold thermoreceptors underlies the unpleasant sensations in dry eye disease

I Kovács, C Luna, S Quirce, K Mizerska, G Callejo… - Pain, 2016 - journals.lww.com
Dry eye disease (DED) affects. 10% of the population worldwide, and it provokes an
unpleasant sensation of ocular dryness, whose underlying neural mechanisms remain …

Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation

J Catapano, SSM Fung, W Halliday, C Jobst… - British Journal of …, 2019 - bjo.bmj.com
Aim To report clinical outcomes and evidence of corneal innervation in patients with
neurotrophic keratopathy (NK) treated with minimally invasive corneal neurotisation (MICN) …

Transient receptor potential channels: important players in ocular pain and dry eye disease

D Fakih, T Migeon, N Moreau, C Baudouin… - Pharmaceutics, 2022 - mdpi.com
Dry eye disease (DED) is a multifactorial disorder in which the eyes respond to minor stimuli
with abnormal sensations, such as dryness, blurring, foreign body sensation, discomfort …

Sensations evoked by selective mechanical, chemical, and thermal stimulation of the conjunctiva and cornea

MC Acosta, ME Tan, C Belmonte… - … ophthalmology & visual …, 2001 - iovs.arvojournals.org
purpose. To study the sensations evoked by selective mechanical, chemical, and thermal
stimulation of the conjunctiva and compare them with those elicited by similar stimulation of …

Analgesic potential of essential oils

JF Sarmento-Neto, LG Do Nascimento, CFB Felipe… - Molecules, 2015 - mdpi.com
Pain is an unpleasant sensation associated with a wide range of injuries and diseases, and
affects approximately 20% of adults in the world. The discovery of new and more effective …

[HTML][HTML] Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea

JA Brock, EM McLachlan, C Belmonte - The Journal of Physiology, 1998 - ncbi.nlm.nih.gov
Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals

R Madrid, T Donovan-Rodríguez… - Journal of …, 2006 - Soc Neuroscience
Transient receptor potential melastatin 8 (TRPM8) is the best molecular candidate for
innocuous cold detection by peripheral thermoreceptor terminals. To dissect out the …

Ocular autonomic nervous system: an update from anatomy to physiological functions

F Wu, Y Zhao, H Zhang - Vision, 2022 - mdpi.com
The autonomic nervous system (ANS) confers neural control of the entire body, mainly
through the sympathetic and parasympathetic nerves. Several studies have observed that …