Pathogenicity and virulence of Staphylococcus aureus

GYC Cheung, JS Bae, M Otto - Virulence, 2021 - Taylor & Francis
Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and
mortality due to an infectious agent. This pathogen can cause a wide variety of diseases …

Staphylococcal biofilm development: structure, regulation, and treatment strategies

K Schilcher, AR Horswill - Microbiology and Molecular Biology …, 2020 - Am Soc Microbiol
In many natural and clinical settings, bacteria are associated with some type of biotic or
abiotic surface that enables them to form biofilms, a multicellular lifestyle with bacteria …

Regulation of Staphylococcus aureus Virulence

C Jenul, AR Horswill - Microbiology spectrum, 2019 - Am Soc Microbiol
Staphylococcus aureus is a Gram-positive opportunistic pathogen that has evolved a
complex regulatory network to control virulence. One of the main functions of this …

Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms

JM Kwiecinski, AR Horswill - Current opinion in microbiology, 2020 - Elsevier
Highlights•Phagocytes play both protective and detrimental roles in containing bloodstream
S. aureus.•S. aureus hijacks the host coagulation system and uses it to bind host …

Quorum-sensing regulation in staphylococci—an overview

KY Le, M Otto - Frontiers in microbiology, 2015 - frontiersin.org
Staphylococci are frequent human commensals and some species can cause disease.
Staphylococcus aureus in particular is a dangerous human pathogen. In staphylococci, the …

The staphylococcal biofilm: adhesins, regulation, and host response

AE Paharik, AR Horswill - Virulence mechanisms of bacterial …, 2016 - Wiley Online Library
The Staphylococcus genus includes a diverse group of commensals that colonize mammals
on the skin or mucous membranes. Some of the best‐known members of this genus, such as …

Staphylococcal biofilms: Challenges and novel therapeutic perspectives

C Kranjec, D Morales Angeles, M Torrissen Mårli… - Antibiotics, 2021 - mdpi.com
Staphylococci, like Staphylococcus aureus and S. epidermidis, are common colonizers of
the human microbiota. While being harmless in many cases, many virulence factors result in …

Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy

C Kong, H Neoh, S Nathan - Toxins, 2016 - mdpi.com
Staphylococcus aureus is an opportunistic pathogen and the leading cause of a wide range
of severe clinical infections. The range of diseases reflects the diversity of virulence factors …

Staphylococcus aureus α-Toxin: Nearly a Century of Intrigue

BJ Berube, J Bubeck Wardenburg - Toxins, 2013 - mdpi.com
Staphylococcus aureus secretes a number of host-injurious toxins, among the most
prominent of which is the small β-barrel pore-forming toxin α-hemolysin. Initially named …

Staphylococcus aureus Infections

FD Lowy - New England journal of medicine, 1998 - Mass Medical Soc
Micrococcus, which, when limited in its extent and activity, causes acute suppurative
inflammation (phlegmon), produces, when more extensive and intense in its action on the …