Tumor development and progression depend on reprogramming of signaling pathways that
regulate cell metabolism. Alterations to various metabolic pathways such as glycolysis …

Comparing single-cell transcriptomic atlases from diverse organisms can elucidate the
origins of cellular diversity and assist the annotation of new cell atlases. Yet, comparison …

KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly
conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and …

Hypertension is one of the leading causes of chronic kidney disease characterized with
renal fibrosis. This study aimed to investigate roles and mechanisms of sirtuin 7 (SIRT7) in …

Abstract N6-methyladenosine (m6A) RNA methylation is profoundly involved in epigenetic
regulation, especially for carcinogenesis and tumor progression. Mounting evidence …

Loss of fatty acid β-oxidation (FAO) in the proximal tubule is a critical mediator of acute
kidney injury and eventual fibrosis. However, transcriptional mediators of FAO in proximal …

Cardiac regeneration requires dedifferentiation and proliferation of mature cardiomyocytes,
but the mechanisms underlying this plasticity remain unclear. Here, we identify a potent …

Spermatogonial stem cells (SSCs) are essential for the generation of sperm and have
potential therapeutic value for treating male infertility, which afflicts> 100 million men world …

Basal cells are multipotent stem cells of a variety of organs, including the respiratory tract,
where they are major components of the airway epithelium. However, it remains unclear …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a dismal prognosis.
Currently, there is no effective therapy for PDAC, and a detailed molecular and functional …