It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the
majority of cell types. Here we review the sources and metabolism of ROS in this organelle …

Addition of hydrogen peroxide (H2O2) is a method commonly used to trigger cellular
oxidative stress. However, the doses used (often hundreds of micromolar) are …

Protocols for high-resolution respirometry (HRR) of intact cells, permeabilized cells, and
permeabilized muscle fibers offer sensitive diagnostic tests of integrated mitochondrial …

Abstract Protocols for High-Resolution FluoRespirometry of intact cells, permeabilized cells,
permeabilized muscle fibers, isolated mitochondria, and tissue homogenates offer sensitive …

Nitrate, an inorganic anion abundant in vegetables, is converted in vivo to bioactive nitrogen
oxides including NO. We recently demonstrated that dietary nitrate reduces oxygen cost …

The recent knowledge on mitochondria as the substantial source of reactive oxygen species,
namely superoxide and hydrogen peroxide efflux from mitochondria, is reviewed, as well as …

Maximal ADP-stimulated mitochondrial respiration depends on convergent electron flow
through Complexes I+ II to the Q-junction of the electron transport system (ETS). In most …

Mitochondria regulate critical components of cellular function via ATP production, reactive
oxygen species production, Ca2+ handling and apoptotic signaling. Two classical methods …

Abstract HIF prolyl hydroxylases (PHD1–3) are oxygen sensors that regulate the stability of
the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that …