Characterizing mechanisms of protein homeostasis, a process of balancing between protein
synthesis and protein degradation, is important for understanding the potential causes of …

Abstract The phosphoinositide 3-kinase (PI3K) signaling pathway is well-known for its
important role in cancer growth, proliferation and migration. The activation of PI3K pathway …

Multiple myeloma (MM), a cancer of plasma cells, is the second most common
hematological malignancy which is characterized by aberrant plasma cells infiltration in the …

Purpose: Proteasome inhibitors (PI) are the backbone of various treatment regimens in
multiple myeloma. We recently described the first in-patient point mutations affecting the 20S …

Normal 121 (85) 35 (90) 31 (79) 66/121 (55) Elevated 18 (13) 3 (8) 6 (15) 9/18 (50)
Unknown 4 (3) 1 (3) 2 (5) 3/4 (75) FISH analysis done, n (%) 132 (92) 34 (87) 36 (92) 70/132 …

Multiple myeloma (MM) is an incurable disease, and patients usually receive multiple lines
of therapy. Due to the abundance of novel treatments for MM, we conducted a network meta …

Relapsed and refractory multiple myeloma (RRMM) presents a therapeutic challenge due to
the development of drug resistance. Panobinostat is an oral histone deacetylase inhibitor …

At present, 20–30% of children with acute leukemia still relapse from current chemotherapy
protocols, underscoring the unmet need for new treatment options, such as proteasome …

Background: The ubiquitin-proteasome pathway is involved in almost all cellular processes
(cell cycle, gene transcription and translation, cell survival and apoptosis, cell metabolism …

Simple Summary The mRNA expression of nine previously described genes that may affect
resistance to multiple myeloma (MM), viz., ABCB1, CXCR4, MAF, MARCKS, POMP, PSMB5 …