Mito‐bomb: targeting mitochondria for cancer therapy

X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

[HTML][HTML] An overview: the diversified role of mitochondria in cancer metabolism

Y Sun, Y Guo, X Shi, X Chen, W Feng… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …

Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics

SR Mishra, KK Mahapatra, BP Behera, S Patra… - … International Journal of …, 2021 - Elsevier
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is responsible for the
sensation of various pathogenic and non-pathogenic damage signals and has a vital role in …

Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology

J Yang, A Griffin, Z Qiang, J Ren - Signal transduction and targeted …, 2022 - nature.com
Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

The dual role of autophagy in cancer development and a therapeutic strategy for cancer by targeting autophagy

CW Yun, J Jeon, G Go, JH Lee, SH Lee - International journal of …, 2020 - mdpi.com
Autophagy is a delicate intracellular degradation process that occurs due to diverse stressful
conditions, including the accumulation of damaged proteins and organelles as well as …

Recent insights into the mitochondrial role in autophagy and its regulation by oxidative stress

V Roca-Agujetas, C de Dios, L Lestón… - Oxidative medicine …, 2019 - Wiley Online Library
Autophagy is a self‐digestive process that degrades intracellular components, including
damaged organelles, to maintain energy homeostasis and to cope with cellular stress …

Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives

S Patra, SR Mishra, BP Behera, KK Mahapatra… - Seminars in cancer …, 2022 - Elsevier
Autophagy is an intracellular catabolic self-cannibalism that eliminates dysfunctional
cytoplasmic cargos by the fusion of cargo-containing autophagosomes with lysosomes to …

Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS–mitochondrial fission–mitophagy axis

M Liu, Y Fan, D Li, B Han, Y Meng, F Chen… - Molecular …, 2021 - Wiley Online Library
Despite recent progress in non‐small‐cell lung cancer (NSCLC) treatment, treatment
outcomes remain poor, mainly because of treatment resistance or toxicity. Erastin is a …

STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib

Y Zheng, C Huang, L Lu, K Yu, J Zhao, M Chen… - Journal of Hematology & …, 2021 - Springer
Background Dysregulation of both mitochondrial biogenesis and mitophagy is critical to
sustain oncogenic signaling pathways. However, the mechanism of mitophagy in promoting …

Caveolin-1 controls mitochondrial damage and ROS production by regulating fission-fusion dynamics and mitophagy

Y Jiang, S Krantz, X Qin, S Li, H Gunasekara, YM Kim… - Redox Biology, 2022 - Elsevier
As essential regulators of mitochondrial quality control, mitochondrial dynamics and
mitophagy play key roles in maintenance of metabolic health and cellular homeostasis. Here …