Mitochondria produce nitric oxide (NO) through a Ca 2+-sensitive mitochondrial NO
synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen …

Protein 3-nitrotyrosine is a posttranslational modification found in many pathological
conditions from acute to chronic diseases. Could 3-nitrotyrosine formation participate on the …

The formation of nitric oxide in biological systems has led to the discovery of a number of
post-translational protein modifications that could regulate protein function or potentially be …

Diabetic neuropathy is the most common complication of diabetes, affecting 50% of diabetic
patients. Currently, the only treatment for diabetic neuropathy is glucose control and careful …

Covalent amino acid modification significantly expands protein functional capability in
regulating biological processes. Tyrosine residues can undergo phosphorylation, sulfation …

The ketone bodies, d-β-hydroxybutyrate and acetoacetate, are soluble 4-carbon compounds
derived principally from fatty acids, that can be metabolised by many oxidative tissues …

Brain tumours lack metabolic versatility and are dependent largely on glucose for energy.
This contrasts with normal brain tissue that can derive energy from both glucose and ketone …

Human SARS‐CoV‐2 infection is characterized by a high mortality rate due to some patients
developing a large innate immune response associated with a cytokine storm and acute …

Reactive oxygen and nitrogen species may cause various types of chemical modifications
on specific proteins, Such modifications if irreversible are often associated with permanent …

Introduction 3. The generation of NO 3.1. Enzymatic Synthesis of NO 3.1. 1. Nitric Oxide
Synthase 3.1. 2. NOS Function Regulation & NOS-2 Selective Inhibition 3.2. NOS …