High levels of reactive species of nitrogen and oxygen in diabetes may cause modifications
of proteins. Recently, an increase in protein tyrosine nitration was found in several diabetic …

Nitric oxide participates in a wide array of physiological processes, ranging from
neurotransmission to precursor of cytotoxic effector molecules of the immune system …

The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) are the subject of
renewed interest given recently established pleiotropic effects regulating inflammation …

Heart muscle is metabolically versatile, converting energy stored in fatty acids, glucose,
lactate, amino acids, and ketone bodies. Here, we use mouse models in ketotic nutritional …

Tamoxifen is an anticancer drug that induces oxidative stress and apoptosis via
mitochondria-dependent and nitric oxide (NO)–dependent pathways. The present report …

Peroxynitrite is the product of the diffusion-controlled termination reaction between two
radicals, nitric oxide and superoxide and is a strong oxidant and nitrating intermediate …

Mitochondria are involved in excitotoxic damage of nerve cells. Following the breakdown of
the calcium‐buffering ability of mitochondria, mitochondrial calcium overload induces …

Mitochondria are primary loci for the intracellular formation and reactions of reactive oxygen
and nitrogen species including superoxide (O2•−), hydrogen peroxide (H2O2) and …

Several reports have described an activity that modifies nitrotyrosine-containing proteins
and their immunoreactivity to nitrotyrosine Abs. Without knowing the product of the reaction …

Cancer cells are well documented to reprogram their metabolism in order to support the
maintenance and reproduction. 3-oxoacid CoA-transferase 1 (OXCT1) is a key enzyme in …