The aim of Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms is to
present recent developments in cell survival and apoptotic pathways and their involvement …

Alcoholic ketoacidosis and diabetic ketoacidosis are life-threatening complications that
share the characteristic features of high anion gap metabolic acidosis. Ketoacidosis is …

We noted differences in the antibody response to 3-nitrotyrosine (NO2Tyr) in fixed and non-
fixed tissues, and studied therefore potential problems associated with non-fixed tissues in …

Fatty acid oxidation is usually thought of as being a preferred ATP source during sepsis, as
shown by the decrease in respiratory quotient in septic patients and animals. However, fatty …

Angiogenesis involves neovascularization or the formation of new capillaries from existing
blood vessels and is associated with the processes of tissue inflammation, wound healing …

Since the nineteenth century, when engineers were using nitroglycerin to blow up rockbeds,
and doctors were prescribing it to relieve angina, scientists have been exploring the …

Reactive oxygen species have an important role in the control of platelet activity. Superoxide
anion (O2−) is a free radical that can be converted into other reactive oxygen species such …

Neonatal sepsis is an important cause of morbidity and mortality as a result of multiple organ
system failure, particularly in neonates requiring total parenteral nutrition. Suitable therapies …

Heart carnitine palmitoyl transferase I (CPTI) is inhibited in vivo during endotoxaemia and in
vitro by peroxynitrite but the biochemical basis of this inhibition is not known. The aim of this …

Although the precise mechanism by which sepsis causes impairment of respiratory muscle
contractility has not been fully elucidated, oxygen-derived free radicals are thought to play …