The matricellular protein thrombospondin (TSP) 1 is induced after tissue injury and may
regulate reparative responses by activating transforming growth factor-β, by suppressing …

Obesity causes extracellular matrix (ECM) remodelling which can develop into serious
pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM …

Cardiac fibrosis has been known to play an important role in the etiology of heart failure after
myocardial infarction (MI). B lymphoma Mo-MLV insertion region 1 homolog (BMI1), a …

Diffuse alveolar injury and pulmonary fibrosis (PF) are the main causes of death of Covid-19
cases. In this study a low molecular weight fucoidan (LMWF) with unique structural was …

TGF-βs regulate fibroblast responses, by activating Smad2 or Smad3 signaling, or via Smad-
independent pathways. We have previously demonstrated that myofibroblast-specific …

Myocardial fibrosis after myocardial infarction (MI) is a leading cause of heart diseases. MI
activates cardiac fibroblasts (CF s) and promotes CF to myofibroblast transformation (CMT) …

The β-galactoside–binding animal lectin galectin-3 is predominantly expressed by activated
macrophages and is a promising biomarker for patients with heart failure. Galectin-3 …

The inability of the heart to recover from an ischemic insult leads to the formation of fibrotic
scar tissue and heart failure. From the therapeutic strategies under investigation, cardiac …

Despite relevant advances made in therapies for cardiovascular diseases (CVDs), they still
represent the first cause of death worldwide. Cardiac fibrosis and excessive extracellular …

Fibrosis is presented in various physiologic and pathologic conditions of the salivary gland.
Transforming growth factor beta (TGF-β) pathway has a pivotal role in the pathogenesis of …