To maintain its high energy demand the heart is equipped with a highly complex and
efficient enzymatic machinery that orchestrates ATP production using multiple energy …

Ketogenesis and ketolysis are central metabolic processes activated during the response to
fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome …

The striking and unexpected relative risk reductions in cardiovascular (CV) mortality (38%),
hospitalization for heart failure (35%), and death from any cause (32%) observed in the …

Type 2 diabetes mellitus causes excessive morbidity and premature cardiovascular (CV)
mortality. Although tight glycemic control improves microvascular complications, its effects …

Only few studies document longer periods of fasting in large cohorts including non-obese
participants. The aim of this study was to document prospectively the safety and any …

For> 50 y, dietary guidelines in the United States have focused on reducing intakes of
saturated and total fat. However, rates of obesity and diabetes rose markedly throughout this …

The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic
effects in multiple organs including brain, heart, and skeletal muscle by serving as an …

Fibroblasts are the most abundant “non-cancerous” cells in tumors. However, it remains
largely unknown how these cancer-associated fibroblasts (CAFs) promote tumor growth and …

Emerging evidence indicates that impaired cellular energy metabolism is the defining
characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal …

Abstract β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel. Although its
contribution to energy metabolism in the healthy brain is minimal, it is an interesting …