Psychedelics and other psychoplastogens for treating mental illness
MV Vargas, R Meyer, AA Avanes, M Rus… - Frontiers in …, 2021 - frontiersin.org
Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike
any treatments currently available. Not only do they produce sustained therapeutic effects …
any treatments currently available. Not only do they produce sustained therapeutic effects …
Molecular mechanisms of psilocybin and implications for the treatment of depression
Therapeutic deficiencies with monoaminergic antidepressants invites the need to identify
and develop novel rapid-acting antidepressants. Hitherto, ketamine and esketamine are …
and develop novel rapid-acting antidepressants. Hitherto, ketamine and esketamine are …
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …
public health implications. A consensus definition of TRD with demonstrated predictive utility …
[HTML][HTML] Single-dose psilocybin for a treatment-resistant episode of major depression: Impact on patient-reported depression severity, anxiety, function, and quality of …
GM Goodwin, ST Aaronson, O Alvarez, M Atli… - Journal of Affective …, 2023 - Elsevier
Background COMP360 is a proprietary, synthetic formulation of psilocybin being developed
for treatment-resistant depression (TRD), a burdensome, life-threatening illness with high …
for treatment-resistant depression (TRD), a burdensome, life-threatening illness with high …
Long-term safety and maintenance of response with esketamine nasal spray in participants with treatment-resistant depression: interim results of the SUSTAIN-3 study
N Zaki, L Chen, R Lane, T Doherty… - …, 2023 - nature.com
Patients with treatment-resistant depression (TRD) have higher rates of relapse and
pronounced decreases in daily functioning and health-related quality of life compared to …
pronounced decreases in daily functioning and health-related quality of life compared to …
Treatment-resistant depression: approaches to treatment
Approximately 30% of people treated for a major depressive episode will not achieve
remission after two or more treatment trials of first-line antidepressants and are considered …
remission after two or more treatment trials of first-line antidepressants and are considered …
Real-world experience of esketamine use to manage treatment-resistant depression: a multicentric study on safety and effectiveness (REAL-ESK study)
Abstract Background Treatment-resistant Depression (TRD) represents a widespread
disorder with significant direct and indirect healthcare costs. esketamine, the S-enantiomer …
disorder with significant direct and indirect healthcare costs. esketamine, the S-enantiomer …
Beyond the 5-HT2A receptor: classic and nonclassic targets in psychedelic drug action
Serotonergic psychedelics, such as psilocybin and LSD, have garnered significant attention
in recent years for their potential therapeutic effects and unique mechanisms of action …
in recent years for their potential therapeutic effects and unique mechanisms of action …
Pharmacotherapies for treatment-resistant depression: how antipsychotics fit in the rapidly evolving therapeutic landscape
One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …
significant improvement after multiple sequential courses of antidepressants and have …
Mechanisms for survival: Vagal control of goal-directed behavior
V Teckentrup, NB Kroemer - Trends in Cognitive Sciences, 2024 - cell.com
Survival is a fundamental physiological drive, and neural circuits have evolved to prioritize
actions that meet the energy demands of the body. This fine-tuning of goal-directed actions …
actions that meet the energy demands of the body. This fine-tuning of goal-directed actions …