The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

V Carlini, DM Noonan, E Abdalalem, D Goletti… - Frontiers in …, 2023 - frontiersin.org
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …

TCM and related active compounds in the treatment of gout: the regulation of signaling pathway and urate transporter

X Sun, L Yang, H Sun, Y Sun, S Wei, Y Han… - Frontiers in …, 2023 - frontiersin.org
Gout represents a metabolic ailment resulting from the accumulation of monosodium urate
crystals within joints, causing both inflammation and, harm to tissues. The primary …

Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice

Y Zhang, S Wang, X Dai, T Liu, Y Liu, H Shi… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Simiao San (SmS), a famous traditional Chinese formula,
is clinically used to treat patients with hyperuricemia (HUA). However, its mechanism of …

Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice

M Lu, J Yin, T Xu, X Dai, T Liu, Y Zhang, S Wang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Fuling-Zexie (FZ) formula, a traditional Chinese
herbal prescription composed of Poria cocos (Schwan.) Wolf.(Poria), Pueraria lobate (Willd.) …

Lactobacillus acidophilus Fermented Dandelion Improves Hyperuricemia and Regulates Gut Microbiota

Q Ma, M Chen, Y Liu, Y Tong, T Liu, L Wu, J Wang… - Fermentation, 2023 - mdpi.com
Foodborne prevention and treatment of hyperuricemia (HUA) has received widespread
attention. Lactic acid bacteria (LAB) can improve intestinal function, while traditional …

Dispelling Dampness, Relieving Turbidity and Dredging Collaterals Decoction, Attenuates Potassium Oxonate-Induced Hyperuricemia in Rat Models

H Liu, M Yang, W Li, T Luo, Y Wu, X Huang… - Drug Design …, 2023 - Taylor & Francis
Purpose Dispelling dampness, relieving turbidity and dredging collaterals decoction (DED),
is a traditional Chinese medicine used in the treatment of hyperuricemia. We aimed to …

Research progress of treating hyperuricemia in rats and mice with traditional Chinese medicine

H Bai, Z Zhang, M Zhu, Y Sun, Y Wang, B Li… - Frontiers in …, 2024 - frontiersin.org
Hyperuricemia (HUA) is a common chronic metabolic disease caused by abnormal purine
metabolism and uric acid excretion. Despite extensive research on HUA, no clear treatment …

Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis

L Muglia, M Di Dio, E Filicetti, GI Greco… - Frontiers in …, 2024 - frontiersin.org
Chronic kidney disease (CKD) in older individuals is a matter of growing concern in the field
of public health across the globe. Indeed, prevalence of kidney function impairment …

Emodin, a Natural Anthraquinone, Increases Uric Acid Excretion in Rats with Potassium Oxonate-Induced Hyperuricemia

SW Hou, SJ Chen, JD Shen, HY Chen, SJ Wang… - Pharmaceuticals, 2023 - mdpi.com
The treatment of hyperuricemia and gout is mostly based on lowering serum uric acid levels
using drugs, such as allopurinol, or increasing urinary excretion of uric acid. However, some …

Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological …

P Quintero-Rincón, Y Pájaro-González… - Advances in Traditional …, 2024 - Springer
Maclura tinctoria (Moraceae), commonly known as dinde, is a lactescent tree of significant
economic importance with extensive ethnomedicinal and ethnobotanical applications …