Klebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution,
insertion, or deletion of amino acid sequence compared to wild bla KPC type, have reduced …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Multidrug-resistant Enterobacterales (MDRE) are an emerging threat to global health,
leading to rising health care costs, morbidity and mortality. Multidrug-resistance is commonly …

Abstract Background Carbapenemase-resistant Enterobacteriaceae (CRE) cause many
serious infections resulting in increasing treatment cost, prolonged hospitalization, and …

Antimicrobial resistance (AMR) is a fundamental global concern analogous to climate
change threatening both public health and global development progress. Infections caused …

β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low
toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms …

Background As cefiderocol is increasingly being prescribed in clinical practice, it is critical
that we understand key mechanisms contributing to acquired resistance to this agent …

ABSTRACT NG-Test Carba 5 is a rapid in vitro multiplex immunoassay for the phenotypic
detection and differentiation of five common carbapenemase families (KPC, OXA-48-like …

The prevalence of carbapenem-resistant Pseudomonas aeruginosa is increasing.
Identification of carbapenemase-producing P. aeruginosa will have therapeutic …

Background MBLs are a major contributor to β-lactam resistance when tested using CAMHB.
Despite in vitro resistance, positive outcomes have been reported in MBL-infected patients …