Abstract Purpose of Review There is considerable interest in using polygenic risk scores
(PRSs) for assessing risk of atherosclerotic cardiovascular disease (ASCVD). A barrier to the …

Polygenic scores (PGS) can be used for risk stratification by quantifying individuals' genetic
predisposition to disease, and many potentially clinically useful applications have been …

Polygenic scores (PGSs) offer the ability to predict genetic risk for complex diseases across
the life course; a key benefit over short-term prediction models. To produce risk estimates …

Background and aims Previous studies on the cost-effectiveness of personalized colorectal
cancer (CRC) screening were based on hypothetical performance of CRC risk prediction …

Background Globally, despite prostate cancer (PCa) representing second most prevalent
malignancy in male, the precise molecular mechanisms implicated in its pathogenesis …

Genome-wide association studies along with expression quantitative trait locus (eQTL)
mapping have identified hundreds of single-nucleotide polymorphisms (SNPs) and their …

Developing novel cancer prevention medication strategies is important for reducing
mortality. Identification of common genetic variants associated with cancer risk suggests the …

A polygenic risk score (PRS) combines the associations of multiple genetic variants that
could be due to direct causal effects, indirect genetic effects, or other sources of familial …

Background Early-onset prostate cancer (EOPC,≤ 55 years) has a unique clinical entity
harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to …

Risk prediction and disease prevention are the innovative care challenges of the 21st
century. Apart from freeing the individual from the pain of disease, it will lead to low medical …