Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease
characterized by insulin deficiency due to pancreatic β-cell loss and leads to …

CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …

BACKGROUND A previous phase I study showed that the infusion of autologous Tregs
expanded ex vivo into patients with recent-onset type 1 diabetes (T1D) had an excellent …

Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of
pancreatic β cells that results in lifelong absolute insulin deficiency. For nearly a century …

Regulatory T cells (Treg) are crucial for the maintenance of peripheral tolerance and for the
control of ongoing inflammation and autoimmunity. The cytokine interleukin-2 (IL-2) is …

Type 1 diabetes (T1D) is an autoimmune disease that occurs in genetically susceptible
individuals. Regulatory T cells (Tregs) have been shown to be defective in the autoimmune …

Interleukin-2 (IL-2) exerts crucial functions during immune homeostasis via its effects on
regulatory T (Treg) cells, and the optimizing and fine-tuning of effector lymphocyte …

Interleukin-2 (IL-2) is integral to immune system regulation. Its opposing immunostimulatory
and immunosuppressive actions make it an attractive therapeutic target for cancer and …

Objective To better define the rare adverse event (AE) of diabetes mellitus associated with
immune checkpoint inhibitors (ICIs). Design and methods We report the case of a lung …

Background An improper balance of regulatory/effector T (T reg/T eff) cells is central to the
development of autoimmune diseases, including type 1 diabetes. We previously showed …